Tyrphostin AG 538 NEW
| Price | $100 | $247 | $372 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Tyrphostin AG 538 | CAS No.: 133550-18-2 |
| Purity: 99.73% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Tyrphostin AG 538 |
| Description | Tyrphostin AG 538 is a chalcone compound, an IGF-1 receptor kinase inhibitor (IC?0 : for 400 nM) that is potent, cell-permeable, reversible, and competitive. |
| In vitro | Experimentally it is indeed found that AG 538 does not compete with ATP but competes with the IGF-1R substrate. Both AG 538 and I-OMe AG 538 inhibit IGR-1R autophosphorylation in intact cells in a dose-dependent manner. Both compounds inhibit the activation of the downstream targets PKB and Erk2.[1] |
| In vivo | Typical assays used to discover and analyze small molecules that inhibit the hepatitis C virus (HCV) NS3 helicase yield few hits and are often confounded by compound interference. FP-based assay was chosen to screen Sigma's Library of Pharmacologically Active Compounds (LOPAC) for compounds that inhibit NS3-DNA complex formation. Four LOPAC compounds inhibited the FP-based assay: aurintricarboxylic acid (ATA) (IC50=1.4?μM), suramin sodium salt (IC50=3.6?μM), NF 023 hydrate (IC50=6.2?μM) and tyrphostin AG 538 (IC50=3.6?μM).[2] |
| Storage | Shipping with blue ice. |
| Solubility Information | DMSO : 4.5 mg/mL (10.5 mM) |
| Keywords | AG-538 | Tyrphostin AG 538 | AG538 | Tyrphostin AG538 | Tyrphostin AG-538 |
| Inhibitors Related | Ceritinib | PD173074 | ALK-IN-1 |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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