Tubulin polymerization-IN-40 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Tubulin polymerization-IN-40 | CAS No.: 2921670-94-0 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Tubulin polymerization-IN-40 |
| Description | Tubulin Polymerization-IN-40 is an acridane-based inhibitor that potently disrupts tubulin polymerization, exhibiting an IC50 of 1.5 μM. It halts cancer cell progression at the G2/M phase, triggers apoptosis, and possesses anti-cancer properties along with immunopotentiating effects [1]. |
| In vitro | Tubulin polymerization-IN-40 (Compound NT-6) exhibited significant antiproliferative efficacy against four cancer cell lines (HCT-116, B16-F10, HeLa, HepG2), with an average IC50 of 30 nM [1]. At concentrations of 10, 25, and 50 nM administered over 48 hours, it effectively induced apoptosis in B16-F10 cells [1]. Furthermore, Tubulin polymerization-IN-40 caused a G2/M phase arrest in B16-F10 cells at the same concentrations after 24 hours [1]. The compound also significantly inhibited colony formation of B16-F10 cells at 50 nM, reducing formation almost completely after 24 hours of treatment [1]. Additionally, Tubulin polymerization-IN-40 dose-dependently inhibited the migration of B16-F10 cells at concentrations of 10, 25, and 50 nM over 24 hours [1]. |
| In vivo | Tubulin polymerization-IN-40 (Compound NT-6; 10 mg/kg; intraperitoneal administration; daily; for 14 days) demonstrated remarkable antitumor efficacy in a melanoma model. When combined with NP-19 (10 mg/kg; intraperitoneal administration), Tubulin polymerization-IN-40 significantly reduced tumor burden (TGI%=77.6%) and enhanced antitumor immune responses [1]. |
| Storage | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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