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TTK21 NEW

Price	$55	$113	$169
Package	1mg	5mg	10mg

Min. Order:
Supply Ability:	10g
Update Time:	2024-11-19

Product Details

Product Name: TTK21	CAS No.: 709676-56-2
Purity: 98.43%	Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

Name	TTK21
Description	TTK21 is an activator of CBP/p300 histone acetyltransferase activity.
In vivo	a small-molecule (TTK21) activator of the histone acetyltransferases CBP/p300, which, when conjugated to glucose-based carbon nanosphere (CSP), passed the blood-brain barrier, induced no toxicity, and reached different parts of the brain.?After intraperitoneal administration in mice, CSP-TTK21 significantly acetylated histones in the hippocampus and frontal cortex.?Remarkably, CSP-TTK21 treatment promoted the formation of long and highly branched doublecortin-positive neurons in the subgranular zone of the dentate gyrus and reduced BrdU incorporation, suggesting that CBP/p300 activation favors maturation and differentiation of adult neuronal progenitors.?In addition, mRNA levels of the neuroD1 differentiation marker and BDNF, a neurotrophin required for the terminal differentiation of newly generated neurons, were both increased in the hippocampus concomitantly with an enrichment of acetylated-histone on their proximal promoter.
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 25 mg/mL (69.88 mM)
Keywords	TTK-21 \| HAT \| histone acetyltransferases \| neurogenesis \| blood–brain barrier \| HATs \| TTK 21 \| inhibit \| TTK21 \| Histone Acetyltransferase \| Inhibitor \| long-term memory \| toxicity \| CSP \| CBP/p300
Inhibitors Related	ABBV-744 \| CeMMEC1 \| 3-methyl-1,2,3,4-tetrahydroquinazolin-2-one \| (+)-JQ-1 \| J-147 \| Anacardic Acid \| Curcumin \| dBET6 \| Piflufolastat \| Naphthol AS-E \| Bisdemethoxycurcumin \| GSK1379725A
Related Compound Libraries	Histone Modification Compound Library \| Bioactive Compound Library \| Epigenetics Compound Library \| NO PAINS Compound Library \| PPI Inhibitor Library \| Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.