Trolox NEW
| Price | $42 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-16 |
Product Details
| Product Name: Trolox | CAS No.: 53188-07-1 |
| Purity: 99.80% | Supply Ability: 10g |
| Release date: 2024/11/16 |
Product Introduction
Bioactivity
| 名稱(chēng) | Trolox |
| 描述 | Trolox is a vitamin E analogue, used in reducing oxidative stress or damage. |
| 體外活性 | METHODS: Human cervical cancer cells HeLa were treated with Trolox (2.5-160 μM) for 24 h and cell viability was measured using MTT assay. RESULTS: Cell viability decreased dose-dependently, with the maximum effect observed at 160 μM Trolox. [1] METHODS: Human skin fibroblasts were treated with Trolox (0.5 mM) for 96 h. The expression levels of target proteins were measured by Western Blot. RESULTS: Trolox increased the mitochondrial levels of Mfn2 in primary human skin fibroblasts without affecting these levels of Drp1 and hFis1. [2] |
| 體內(nèi)活性 | METHODS: To investigate the neuroprotective effects, Trolox (50 mg/kg) was intraperitoneally injected once a day for ten days into an MPTP-induced Parkinson's disease mouse model. RESULTS: Trolox may exert neuroprotective effects on dopaminergic neurons against MPTP-induced oxidative stress, neuroinflammation, motor dysfunction and neurodegeneration. [3] |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (19.98 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. DMSO : 50 mg/mL (199.77 mM) |
| 關(guān)鍵字 | Trolox | Reactive Oxygen Species | Inhibitor | inhibit | Ferroptosis | Apoptosis |
| 相關(guān)產(chǎn)品 | Stavudine | 5-Fluorouracil | Acetylcysteine | Imeglimin hydrochloride | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | L-Ascorbic acid | Tributyrin | Curcumin | L-Cystine | Salicylic acid | Oleic acid |
| 相關(guān)庫(kù) | NF-κB 通路分子庫(kù) | 經(jīng)典已知活性庫(kù) | 抗卵巢癌化合物庫(kù) | 抗肥胖化合物庫(kù) | 抑制劑庫(kù) | 線粒體靶向庫(kù) | 抗前列腺癌化合物庫(kù) | 代謝化合物庫(kù) | 免疫/炎癥分子化合物庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) | 抗癌化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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