Trimethylamine N-oxide NEW
| Price | $29 |
| Package | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-28 |
Product Details
| Product Name: Trimethylamine N-oxide | CAS No.: 1184-78-7 |
| Supply Ability: 10g | Release date: 2025/04/28 |
Product Introduction
Bioactivity
| Name | Trimethylamine N-oxide |
| Description | Trimethylamine N-oxide (TMAO) is a colorless amine oxide produced from choline, betaine, and carnitine via intestinal microbial metabolism that accumulates in tissues of marine animals and prevents the protein-damaging effects of urea.Trimethylamine N-oxide induces inflammation through activation of ROS/NLRP3 inflammasomes, which can induce fibroblast differentiation and cardiac fibrosis. |
| In vitro | In vitro, the treatment of fibroblasts with Trimethylamine N-oxide (TMAO) results in an increase in both the size and migration of fibroblasts compared to untreated fibroblasts. TMAO induces an elevation in TGF-β receptor I expression, leading to the phosphorylation of Smad2 and an up-regulation in the expression of α-SMA and collagen I. Concurrently, the ubiquitination of TGF-βRI is decreased in neonatal mouse fibroblasts following Trimethylamine N-oxide treatment. Additionally, Trimethylamine N-oxide inhibits the expression of smurf2 [3]. Trimethylamine N-oxide is commonly found in the tissues of various marine organisms, where it serves as a protective factor against the adverse effects of temperature, salinity, high urea, and hydrostatic pressure [2]. |
| In vivo | Trimethylamine N-oxide can be utilized in animal modeling to establish a model of cardiac fibrosis. |
| Storage | keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 40 mg/mL (532.55 mM), Sonication is recommended. H2O : 10 mg/mL (133.14 mM), Sonication is recommended. |
| Keywords | Trimethylamine N-oxide | Trimethylamine Noxide | Trimethylamine N oxide | TGF-β/Smad | TGFβ | TGF-beta/Smad | TGFbeta/Smad | TGF-beta | TGFbeta | TGF-b/Smad | TGFb | Smad | ReactiveOxygenSpecies | Reactive Oxygen Species | NODlikeReceptor(NLR) | NODlikeReceptor | NOD-like Receptor (NLR) | NODlike Receptor (NLR) | NOD-like Receptor | NLR | Metabolism |
| Inhibitors Related | Stavudine | Sodium Thiocyanate | Acetylcysteine | Imeglimin hydrochloride | L-Ascorbic acid | Dimethyl fumarate | Glucosamine | D-(+)-Glucono-1,5-lactone | Lycopene | L-Ascorbic acid sodium salt | Sodium 2-oxopropanoate | Naringenin |
| Related Compound Libraries | Bioactive Compound Library | Anti-Ovarian Cancer Compound Library | Food Additive Library | Natural Product Library | Microbial Natural Product Library | Stem Cell Differentiation Compound Library | Natural Product Library for HTS | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Cosmetic Ingredient Compound Library | Bioactive Compounds Library Max | TGF-beta/Smad Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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