Trimethylacetamide (CAS: 754-10-9)

Physical and Chemical Properties

Chemical Information

• IUPAC Name: N,N-Dimethyl-2,2-dimethylpropanamide

• Synonyms: Trimethylacetamide, N,N-Dimethylpivalamide

• Molecular Formula: C7H15NO

• Molecular Weight: 129.20 g/mol

Structure and Properties

• Chemical Structure: Trimethylacetamide consists of a central carbon atom bonded to three methyl groups and an acetamide group (N,N-dimethylacetamide structure with an additional methyl group).

• Appearance: Typically a colorless to pale yellow liquid.

• Boiling Point: Approximately 194°C (381.2°F)

• Melting Point: Approximately -15°C (5°F)

• Density: Approximately 0.89 g/cm3 at 25°C

Applications and Uses

• Solvent: Commonly used as a solvent in organic synthesis due to its stability and ability to dissolve a wide range of compounds.

• Chemical Intermediate: Utilized in the production of pharmaceuticals, agrochemicals, and other organic compounds.

• Catalyst and Reagent: Used in various chemical reactions and processes as a reagent and catalyst.

Safety and Handling

• Personal Protective Equipment (PPE): Use appropriate gloves, protective eyewear, and lab coats to prevent contact with skin and eyes.

• Storage: Store in a cool, dry, well-ventilated area, away from incompatible substances such as strong oxidizing agents.

• Hazards: Can cause skin and eye irritation. Inhalation of vapors may cause respiratory tract irritation.

• First Aid Measures:

• Inhalation: Move to fresh air. If not breathing, give artificial respiration and seek medical attention.

• Skin Contact: Wash off with soap and plenty of water. Remove contaminated clothing and shoes.

• Eye Contact: Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

• Ingestion: Rinse mouth with water. Do not induce vomiting. Seek medical attention.

Resources and References

Trimethylacetamide is a versatile solvent and chemical intermediate used in various industrial and research applications. For precise safety guidelines, always refer to the specific Material Safety Data Sheet (MSDS) provided by the manufacturer or supplier.