Triglycidyl isocyanurate NEW
| Price | $33 |
| Package | 1g |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Triglycidyl isocyanurate | CAS No.: 2451-62-9 |
| Purity: 99.01% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Triglycidyl isocyanurate |
| Description | Triglycidyl isocyanurate (Teroxirone) is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. It induces cell apoptosis and can be used for cancer research[1][2]. Triglycidyl isocyanurate is also used in various polyester powder coatings in the metal finishing industry. |
| Cell Research | Triglycidyl isocyanurate (0-30 μM; 48?hours) Inhibited tumor cells(A549, H460 and H1299 cells)growth in soft agar. Triglycidyl isocyanurate (0-30 μM; 48?hours) inhibited akt1/2/3 expression and p-aktser473/474/472 expression of A549, H460 and H1299 tumorspheres. |
| Animal Research | Triglycidyl isocyanurate (Female nu/nu mice with Huh7 cells subcutaneously injected into the dorsal area; 1.8 and 3.6 mg/kg; every 2–3 days for total seven times; 30 days)Inhibited the growth of xenograft tumors[2]. |
| In vitro | Triglycidyl isocyanurate (0-30 μM; 48?hours) inhibits expression of akt1/2/3 and phosphorylated Aktser473/474/472 of A549, H460 and H1299 tumorspheres, however, the cleavage of PARP and procaspase-3 plus the emergent active caspase-3 fragment are only visible in H460 and A549 tumorspheres[1]. Triglycidyl isocyanurate (0-30 μM; 48?hours) reduces the growth of spheroids of human non-small-cell-lung cancer cells in culture, it leads to a gradual reduction in size for tumorspheres of A549, H460 and H1299 cells[1]. |
| In vivo | Triglycidyl isocyanurate (subcutaneous injection; 1.8 and 3.6 mg/kg; every 2-3 days for a total of seven doses over 30 days) suppresses xenograft tumor growth without affecting weight in nude mice[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (168.2 mM) |
| Keywords | Triglycidyl isocyanurate | hepatocellular | Apoptosis | Hep3B | Inhibitor | HCC | tumor | inhibit | anticancer agent | liver cancer | carcinoma | NSCLC | HepG2 | MDM-2/p53 |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Acetylcysteine | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Metronidazole | Sorafenib | Tributyrin |
| Related Compound Libraries | Anti-Colorectal Cancer Compound Library | Anti-Lung Cancer Compound Library | Bioactive Compound Library | Ubiquitination Compound Library | ReFRAME Related Library | Anti-Cancer Metabolism Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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