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Postion:Product Catalog >API>Antineoplastic agents>Natural sources of antineoplastic>Topotecan hydrochloride
Topotecan hydrochloride
  • Topotecan hydrochloride
  • Topotecan hydrochloride
  • Topotecan hydrochloride
  • Topotecan hydrochloride
  • Topotecan hydrochloride

Topotecan hydrochloride NEW

Price Get Latest Price
Package 25kg
Min. Order: 1kg
Supply Ability: 2000ton
Update Time: 2024-04-12

Product Details

Product Name: Topotecan hydrochloride CAS No.: 119413-54-6
EC-No.: 601-607-9 Min. Order: 1kg
Purity: 99% Supply Ability: 2000ton
Release date: 2024/04/12
Appearance: White Powder

Topotecan hydrochloride is a water-soluble camptothecin derivative, which is the hydrochloride form of Topotecan. It was successfully developed by SmithKlineBeecham Company in the United States and approved by FDA in 1996 under the product name Hycamtin for the treatment of ovarian cancer (OVC) as a second-line therapeutic drug. In 1999, the United States Food and Drug Administration (FDA) approved Topotecan hydrochloride as a treatment for small cell lung cancer (SCLC), which has been listed in dozens of countries and regions such as the United Kingdom, Germany and France. Phase III clinical trials for the treatment of non-small cell lung cancer, cervical cancer and myelodysplastic syndrome are ongoing. Topotecan hydrochloride can enter the blood-brain barrier, is orally as effective as intravenous administration, has low predictable myelosuppressive toxicity, and other non-hematological toxicity is less severe. At present, it has been produced by domestic manufacturers for the clinical treatment of small cell lung cancer, ovarian cancer and other tumors. Topotecan hydrochloride inhibits the activity of topoisomerase I, which is required for DNA replication. After intravenous injection, this product is hydrolyzed in the blood and excreted in urine. This product has a rapid serum clearance rate of 62L per hour, widely distributed in the body, and a half-life of about 2 to 3h. Preclinical tests showed that this product has antitumor activity against all kinds of tumor species. In Phase I clinical trials, this product also has significant antitumor effects on cisplatin resistant ovarian cancer patients.

 

 

Adverse reaction

In the limited dose of this product can appear bone marrow suppression and other toxic reactions, especially can cause neutropenia. It also often causes thrombocytopenia and anemia, sometimes requiring transfusions of red blood cells and platelets. Nausea, vomiting, hair loss, diarrhea, abdominal pain, gastritis and weakness may also occur, but they are mild.

 

Application:

1 Used as an antitumor agent

2 A topoisomerase I inhibitor.

Storage Condition

Keep in a cool and dry place

Transportation

By Sea or by Air(DHL/UPS/TNT/FEDEX/EMS)

Delivery Time

7-28 days

Payment

T/T, Western Union or Bitcoin

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Company Profile Introduction

Xi'an Haibo Biotechnology Co.,Ltd. is specialized in the study, production and sale of natural plant extract products,which are used in pharmaceuticaldietary supplement, food and cosmetic industries. Our company is located in Xian National High-tech Industrial Development Zone. Xian Haibo Biotech Co.,Ltd. has a number of departments including R&D, production, quality inspection, and market. The company's R&D center has a technical team specializing in research and developmentas well as advanced detection systems such as high-performance liquid chromatography, gas chromatography,and magnetic drive autoclave, experimental, pilot plant,and a number of scientific research institutions have established a good technical support relationship,with strong technical force. The company's production workshop has several plant extraction production lines, as well as advanced production equipment such as dynamic countercurrent extraction,column separatio

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  • Since: 2020-08-05
  • Address: 804, Unit 2, Building 4, i City, No. 11, South Tangyan Road, High-tech Zone, Xi 'an, Shaanxi
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