Topoisomerase I inhibitor 2 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-28 |
Product Details
| Product Name: Topoisomerase I inhibitor 2 | CAS No.: 2588211-44-1 |
| Supply Ability: 10g | Release date: 2025/04/28 |
Product Introduction
Bioactivity
| Name | Topoisomerase I inhibitor 2 |
| Description | Topoisomerase I inhibitor 2 (ZML-8) is a highly selective DNA topoisomerase I (Top1) inhibitor that impedes Top1 activity, causing DNA damage. It arrests the cell cycle at the G2/M phase and induces apoptosis, exhibiting anti-tumor effects [1]. |
| In vitro | Topoisomerase I inhibitor 2 demonstrates potent inhibitory effects on HepG2 cells with an IC50 of 0.58 μM and exhibits selectivity, with a selectivity index (SI) of 55.70% between HepG2 and normal human liver cells L-02 [1]. When administered at concentrations of 1.25 and 2.5 μM for 48 hours, it significantly suppresses tumor cell proliferation. This suppression is achieved through the downregulation of the anti-apoptotic protein Bcl-2 and the promotion of caspase-dependent apoptosis, alongside a decrease in Top1 activity leading to DNA damage via supercoiled DNA formation [1]. Additionally, cell cycle analysis reveals that at a concentration of 2.5 μM, there is a dose-dependent arrest in the G2/M phase within 24 hours. Further assays confirm that the apoptosis rate increases in a dose-dependent manner upon exposure for 48 hours, with rates of 65.0% and 77.6%. Moreover, Western blot analysis at concentrations of 0.625, 1.25, and 2.5 μM over 48 hours shows a significant decrease in Bcl-2 expression and an increase in pro-apoptotic proteins Bax, Bad, and p53, signifying the enhancement of caspase-dependent apoptosis and activation of Cleaved caspase-3 [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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