Topiramate NEW
| Price | $38 | $50 | $65 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: Topiramate | CAS No.: 97240-79-4 |
| Purity: ≥95% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱(chēng) | Topiramate |
| 描述 | Topiramate (RWJ 17021) is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associated with hepatic injury and largely when used in combination with other anticonvulsant medications. |
| 體外活性 | Intraperitoneal injection of 20 and 40 mg/kg topiramate demonstrated a dose-dependent inhibition of both tonic convulsions and absence seizures. Intraperitoneal administration of topiramate at doses ranging from 25-100 mg/kg dose-dependently increased the threshold for pentylenetetrazol (PTZ)-induced clonic seizures. Topiramate was dose-effectively potent in suppressing acute seizures induced by perinatal hypoxia, with an ED50 of 2.1 mg/kg. Additionally, in DBA/2 mice, topiramate inhibited audiogenic seizures, confirming its anticonvulsant efficacy. |
| 體內(nèi)活性 | In whole-cell voltage-clamp recordings from principal neurons of the basolateral nucleus of the rat amygdala, low concentrations of Topiramate selectively inhibit excitatory postsynaptic currents (EPSCs) mediated by pharmacologically isolated kainate receptors that contain the GluR5 subunit. Topiramate also noticeably reduces AMPA receptor-mediated EPSCs, albeit with less potency. Additionally, Topiramate slightly inhibits the sustained component of Na+ currents in isolated neurons, and after blocking Ca2+ and K+ currents, diminishes the peak of Na+-dependent persistent action potentials induced in layer V pyramidal neurons. The compound selectively inhibits synaptic responses mediated by the GluR5 kainate receptor. Moreover, Topiramate impedes the action of voltage-sensitive Na+ channels and non-N-methyl-D-aspartate receptors, while potentiating inhibition mediated by gamma-aminobutyric acid (GABA). |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 55 mg/mL (162.07 mM) Ethanol : 33.9 mg/mL (100 mM) |
| 關(guān)鍵字 | Ca2+ channels | inhibit | Calcium Channel | Na channels | Topiramate | Carbonic Anhydrase | KcsA | RWJ17021 | iGluR | Sodium Channel | γ-Aminobutyric acid Receptor | Carbonate dehydratase | McN-4853 | GABA Receptor | Ionotropic glutamate receptors | RWJ-17021 | Ca channels | Na+ channels | Potassium Channel | Gamma-aminobutyric acid Receptor | McN4853 | Inhibitor |
| 相關(guān)產(chǎn)品 | Phenytoin sodium | L-Ascorbic acid | Lidocaine hydrochloride |
| 相關(guān)庫(kù) | 神經(jīng)退行性疾病化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 膜蛋白靶向化合物庫(kù) | EMA 上市藥物庫(kù) | 抗癌臨床化合物庫(kù) | 抗癌上市藥物庫(kù) | FDA 上市藥物庫(kù) | 離子通道庫(kù) | 抗癌藥物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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