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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Neuronal Signaling>5-HT Receptor agonists>Tianeptine Sodium Salt
Tianeptine Sodium Salt
  • Tianeptine Sodium Salt

Tianeptine Sodium Salt

Price $10
Package 1kg
Min. Order: 1kg
Supply Ability: 1ton
Update Time: 2022-11-05

Product Details

Product Name: Tianeptine Sodium Salt CAS No.: 30123-17-2
EC-No.: 200-001-8 Min. Order: 1kg
Purity: 99.8% Supply Ability: 1ton
Release date: 2022/11/05
CAS Number 30123-17-2 Molecular Weight 458.934
Density 1.38 g/cm3 Boiling Point 609.2oC at 760 mmHg
Molecular Formula C21H24ClN2NaO4S Melting Point 1800C
MSDS Chinese USA Flash Point 322.2oC

Tianeptine Sodium Salt Biological Activity

Description Tianeptine sodium salt is a selective facilitator of 5-HT uptake in vitro and in vivo. IC50 Value:Target: 5-HT ReceptorTianeptine has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50 > 10 μM) and has no effect on noradrenalin or dopamine uptake. Antidepressant, analgesic and neuroprotective following systemic administration in vivo.
Related Catalog
Signaling Pathways >>       GPCR/G Protein >>       5-HT Receptor  
Signaling Pathways >>       Neuronal Signaling >>       5-HT Receptor  
Research Areas >>       Neurological Disease  
Solvent
In Vitro:

H2O : ≥ 235 mg/mL (512.06 mM)

* "≥" means soluble, but saturation unknown.

Solubility 1 mM2.1790 mL10.8949 mL21.7898 mL5 mM0.4358 mL2.1790 mL4.3580 mL10 mM0.2179 mL1.0895 mL2.1790 mL
Storage Powder-20°C3 years 4°C2 yearsIn solvent-80°C6 months -20°C1 month
Shipping Room temperature in continental US; may vary elsewhere
SMILES O=C(CCCCCCNC(C1=CC=CC=C1N2C)C3=CC=C(C=C3S2(=O)=O)Cl)[O-].[Na+]
References

[1]. Broqua P; Baudrie V; Chaouloff F Differential effects of the novel antidepressant tianeptine on L-5-hydroxytryptophan (5-HTP)-elicited corticosterone release and body weight loss. Eur Neuropsychopharmacol. 1992 Jun;2(2):115-20.

[2]. Orescanin-Dusic Z, et al. Tianeptine's effects on spontaneous and Ca2+-induced uterine smooth muscle contraction. Acta Physiol Hung. 2012 Jun;99(2):140-7.

[3]. Della FP, Abelaira HM, Réus GZ, Ribeiro KF, Antunes AR, Scaini G, Jeremias IC, Dos Santos LM, Jeremias GC, Streck EL, Quevedo J.Tianeptine treatment induces antidepressive-like effects and alters BDNF and energy metabolism in the brain of rats.Behav Brain Res. 2012 Aug 1;233(2):526-35. Epub 2012 May 31.

[4]. Sohn W, Lee OY, Kwon JG, Park KS, Lim YJ, Kim TH, Jung SW, Kim JI.Tianeptine vs amitriptyline for the treatment of irritable bowel syndrome with diarrhea: a multicenter, open-label, non-inferiority, randomized controlled study.Neurogastroenterol Motil. 2012 Sep;24(9):860-e398.

[5]. Orola L, Veidis MV, Sarcevica I, Actins A, Belyakov S, Platonenko A.The effect of pH on polymorph formation of the pharmaceutically active compound tianeptine.Int J Pharm. 2012 Aug 1;432(1-2):50-6. Epub 2012 Apr 30.

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Chemical & Physical Properties

Density 1.38 g/cm3
Boiling Point 609.2oC at 760 mmHg
Melting Point 1800C
Molecular Formula C21H24ClN2NaO4S
Molecular Weight 458.934
Flash Point 322.2oC
Exact Mass 458.104309
PSA 97.92000
LogP 4.39460
Storage condition Desiccate at RT

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