Thiabendazole NEW
| Price | $40 |
| Package | 5g |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-13 |
Product Details
| Product Name: Thiabendazole | CAS No.: 148-79-8 |
| Purity: 99.94% | Supply Ability: 10g |
| Release date: 2024/11/13 |
Product Introduction
Bioactivity
| 名稱 | Thiabendazole |
| 描述 | Thiabendazole (2-(4-Thiazolyl)benzimidazole) is a benzimidazole derivative with anthelminthic property. |
| 體外活性 | Thiabendazole provokes a strong DNA-damaging activity in the human lymphoblastoid cell line that constitutively expresses human CYP1A1 cDNA, but not in the parental line, indicating that CYP1A1 is chiefly implicated in carbaryl and thiabendazole genotoxicity. [1] Thiabendazole provokes a dose- and time-dependent increase in CYP1A1 (EROD activity, protein and mRNA levels) in primary culture of rat hepatocytes. [2] Thiabendazole results in the induction of 7-ethoxyresorufin O-deethylase and 7-pentoxyresorufin O-depentylase activities, CYP1A1, CYP1A2, CYP2B1 and CYP2B1/2 mRNA levels and CYP1A2 and CYP2B1/2 apoprotein levels. Thiabendazole markedly induces GSTP1 mRNA levels, but has only a small effect on GSTT1 mRNA levels. [3] Thiabendazole is rapidly transported by passive diffusion through the human intestinal cells by comparison with the protein-bound residues which are not able to cross the intestinal barrier. Thiabendazole will be firstly metabolized to 5OH-TBZ and subsequently converted to a chemically reactive metabolic intermediate binding to proteins. [4] |
| 體內(nèi)活性 | Thiabendazole results in nephrosis or hydronephrosis and this organ toxicity may lead to the high dose-dependent mortality in treated mice. Thiabendazole results in hormone imbalance and this imbalance may play an important role in the changes of the reproductive or endocrine system in treated mice. [5] |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : 1 mg/mL (4.96 mM) DMSO : 3.85 mg/mL (19.11 mM), Sonication is recommended. |
| 關(guān)鍵字 | Parasite | Mitochondrial Metabolism | Thiabendazole | inhibit | Inhibitor |
| 相關(guān)產(chǎn)品 | Picaridin | Kaempferol | Rotenone | Hydroxychloroquine | Metronidazole | Nitazoxanide | Doxycycline | Chloroquine phosphate | Diethyltoluamide | Artemisinin | Benzyl benzoate | DL-Methionine |
| 相關(guān)庫 | 抗寄生蟲庫 | 藥物功能重定位化合物庫 | 煙草單體化合物庫 | 抗寄生蟲天然產(chǎn)物庫 | 抗衰老化合物庫 | 化妝品成分化合物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $40.00/5g |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-13 | |
| $10.00/1kg |
VIP6Y
|
Hebei Weibang Biotechnology Co., Ltd
|
2024-10-25 | |
| $0.00/25kg |
VIP4Y
|
qingdao trust agri chemical co.,ltd
|
2024-07-12 | |
| $10.00/1KG |
VIP1Y
|
Henan Fengda Chemical Co., Ltd
|
2024-04-28 | |
| $1.00/1KG |
Ouhuang Engineering Materials (Hubei) Co., Ltd
|
2024-04-26 | ||
| $0.00/1Kg |
VIP1Y
|
airuikechemical co., ltd.
|
2024-04-09 | |
| $0.00/1kg |
VIP5Y
|
Hebei Yanxi Chemical Co., Ltd.
|
2023-09-25 | |
| $0.00/25KG |
VIP5Y
|
Hebei Mojin Biotechnology Co., Ltd
|
2023-09-07 | |
| $100.00/1bag |
Hebei Fengqiang Trading Co., LTD
|
2023-08-28 | ||
| $35.00/1KG |
XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
|
2021-12-21 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY