Thailanstatin A NEW
| Price | $197 | $327 | $579 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-11 |
Product Details
| Product Name: Thailanstatin A | CAS No.: 1426953-21-0 |
| Purity: 99.35% | Supply Ability: 10g |
| Release date: 2024/11/11 |
Product Introduction
Bioactivity
| 名稱 | Thailanstatin A |
| 描述 | Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50 = 650 nM). It inhibits multiple cancer cell lines via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome, displaying low-nM to sub-nM IC50s. Thailanstatin A, as a payload for ADCs, is conjugated to the lysines on trastuzumab, yielding linker-less ADC. |
| 體外活性 | Thailanstatin A (TST-A) is a potent antiproliferative natural product discovered by our group from Burkholderia thailandensis MSMB43 [2]. Thailanstatin A (DU-145, NCI-H232A, MDA-MB-231 and SKOV-3 cells) shows potent antiproliferative activities with GI 50 s in the single nM range (1.11-2.69 nM) [3]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 245 mg/mL (457.41 mM), Sonication is recommended. |
| 關(guān)鍵字 | ADC Payload | natural | Inhibitor | inhibit | SF3b | subunit | antiproliferative | Thailanstatin A | spliceosome | ADC | ADC Cytotoxin | RNA | linker |
| 相關(guān)產(chǎn)品 | Methotrexate | Mertansine | Doxorubicin hydrochloride | Daunorubicin hydrochloride | Exatecan | Camptothecin | Dexamethasone acetate | Dexamethasone | Fluticasone (propionate) | Paclitaxel |
| 相關(guān)庫(kù) | 微生物天然產(chǎn)物庫(kù) | 抗癌化合物庫(kù) | 抗癌活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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