TH1020 NEW

Price	$39	$64	$97
Package	2mg	5mg	10mg

Min. Order:
Supply Ability:	10g
Update Time:	2024-11-19

Product Details

Product Name: TH1020	CAS No.: 1841460-82-9
Purity: 99.23%	Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

Name	TH1020
Description	TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity.
In vivo	TH1020 was repress the expression of downstream TNF-α signaling pathways mediated by the TLR5/flagellin complex formation.?Based on molecular docking simulation, TH1020 is suggested to compete with flagellin and disrupt its association with TLR5.?TH1020 provides a much-needed molecular probe for studying this important protein-protein interaction and a lead compound for identifying novel therapeutics targeting TLR5.
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 4.54 mg/mL (10 mM), Sonication is recommended.
Keywords	interaction \| inhibit \| Bacterial \| flagellin \| Toll-like Receptor (TLR) \| TLR5 \| protein-protein \| TH-1020 \| TH1020 \| TNF-α \| Inhibitor \| TH 1020
Inhibitors Related	Neomycin sulfate \| Dehydroacetic acid sodium \| Ampicillin sodium \| Methyl anthranilate \| Kanamycin sulfate \| G-418 disulfate \| Sulfamethoxazole sodium \| Hydroxychloroquine \| Metronidazole \| Doxycycline \| Dimethyl sulfoxide \| Crystal Violet
Related Compound Libraries	Bioactive Compound Library \| Membrane Protein-targeted Compound Library \| Drug-induced Liver Injury (DILI) Compound Library \| Pyroptosis Compound Library \| Antibiotics Library \| Inhibitor Library \| Anti-Bacterial Compound Library \| NO PAINS Compound Library \| Bioactive Compounds Library Max \| Anti-Infection Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.