Overview Tetracaine hydrochloride is a highly effective local anesthetic that can reverse block nerve function. It is used in infiltration anesthesia, nerve block anesthesia, epidural anesthesia, etc. Compared with procaine, its local anesthetic effect is remarkable, and it has been widely used in clinic. It is found that the synthesis of p-butylaminobenzoic acid is the key step in the synthesis of tetracaine hydrochloride, which always has the disadvantages of unstable raw materials or low yield. Scientists have improved and improved this, in 1981 proposed to synthesize p-butylaminobenzoic acid by alkylation of p-aminobenzoic acid with 1-bromobutane, but because it can not avoid the generation of double butylated by-products, and the nature of the raw material itself is unstable, making this route is not suitable for industrial production. Indications Tetracaine hydrochloride is used in Chemicalbook mucosal surface anesthesia, conduction anesthesia, epidural anesthesia and subarachnoid anesthesia. It is used for ophthalmic surface anesthesia without constricting blood vessels, damaging corneal epithelium and increasing intraocular pressure. Action Tetracaine hydrochloride is a kind of long-acting ester local anesthetic, its action characteristics are: strong penetration of mucosa, suitable for surface anesthesia, often used in ophthalmology. After injection, the anesthetic effect appears slow (about 10 minutes), the post-absorption metabolism is also slow, and the local anesthesia time is as long as 3IJ, H,-J. Around. There were no adverse reactions such as vasoconstriction, dilated pupil and corneal injury after tetracaine hydrochloride, and the local anesthetic effect and toxicity were about 10 times greater than that of procaine. It is mainly used for surface anesthesia of the mucous membranes of the eyes, nose and throat, and rarely used for conduction anesthesia and epidural anesthesia. It is generally not used for infiltration anesthesia due to high toxicity

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