Terbinafine hydrochloride NEW
| Price | $32 | $88 |
| Package | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-17 |
Product Details
| Product Name: Terbinafine hydrochloride | CAS No.: 78628-80-5 |
| Purity: 99.89% | Supply Ability: 10g |
| Release date: 2024/11/17 |
Product Introduction
Bioactivity
| 名稱 | Terbinafine hydrochloride |
| 描述 | Terbinafine hydrochloride (KWD 2019) is a synthetic allylamine derivative structurally related to naftifine. Terbinafine is active against dermatophytes. |
| 體外活性 | Terbinafine (50 μM to 100 μM) inhibits only marginally the metabolism of ethoxycoumarin (CYP1A2), tolbutamide (CYP2C9), or ethynylestradiol, CsA, and cortisol. Terbinafine proves to be a potent inhibitor of the CYP2D6-mediated dextromethorphan O-demethylation and bufuralol 1-hydroxylation with IC50values of 0.2 μM and 0.25 μM, respectively. [1] Terbinafine is highly activ Aspergillus isolates (minimum inhibitory concentration [MIC] 0.01 to 2 mg/mL) with a primary fungicidal action (minimum fungicidal concentration [MFC] 0.02 to 4 mg/mL). [2] Terbinafine inhibits dextromethorphan O-demethylation with an apparent Ki ranging from 28 to 44 nM in human hepatic microsomes and averaging 22.4 nM for the heterologously expressed enzymes. [3] Terbinafine shows a very strong activity in vitro against Penicillium spp., Paecilomyces spp., Trichoderma spp., Acremonium spp. and Arthrographis spp. with GMs <1 mg/L. [4] Terbinafine decreases the levels of phosphorylated extracellular signal-regulated kinase (ERK). Terbinafine might cause a decrease of MEK, which in turn up-regulates p53 through the inhibition of ERK phosphorylation, and finally causes an increase of p21expression and cell-cycle arrest. [5] |
| 體內(nèi)活性 | Terbinafine demonstrates efficacy both as a topical application and through oral administration in experimental dermatophytoses. Notably, in guinea pigs infected with fungi, a significant decrease in skin temperature is observed after the fourth terbinafine treatment[6]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (152.49 mM), Sonication is recommended. |
| 關(guān)鍵字 | bacteria | Fungal | antibacterial activity | TDT-067 | infections | Bacterial | KWD-2019 | TDT 067 Hydrochloride | TDT-067 Hydrochloride | TDT067 Hydrochloride | Inhibitor | TDT067 | KWD2019 | Terbinafine hydrochloride | squalene epoxidase | Candida | Terbinafine Hydrochloride | Terbinafine | inhibit | Antibiotic | TDT 067 |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | EMA 上市藥物庫 | 天然產(chǎn)物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | 高通量篩選天然產(chǎn)物庫 | FDA 上市藥物庫 | 抗感染天然產(chǎn)物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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