Tenofovir
Price | Get Latest Price | ||
Package | 1Kg/Bag | 25Kg/Bag | 100Kg/Bag |
Min. Order: | 0.1Kg/Bag |
Supply Ability: | 20 tons |
Update Time: | 2024-12-23 |
Product Details
Product Name: Tenofovir | CAS No.: 147127-20-6 |
EC-No.: 604-571-2 | Min. Order: 0.1Kg/Bag |
Purity: 99% min, GMP | Supply Ability: 20 tons |
Release date: 2024/12/23 |
Product Information
API Powder 99% Tenofovir CAS 147127-20-6
Tenofovir, chemical name R-9-(2-phosphate methoxypropyl) adenine (PMPA), molecular formula C9H14N5O4P, is a nucleotide reverse transcriptase inhibitor.
Nucleotide analogs reverse transcriptase inhibitors can block HIV replication. Combined with other antiretroviral drugs to treat HIV-1 infection. Used in the treatment of AIDS.
Melting point | 276-280°C |
alpha | D +21° (c = 1 in 0.1M HCl) |
Boiling point | 616.1±65.0 °C(Predicted) |
density | 1.79±0.1 g/cm3(Predicted) |
storage temp. | -20°C |
pka | 2.36±0.10(Predicted) |
form | powder |
color | white to beige |
optical activity | [α]/D -20 to -26°, c = 0.5 in 1 M HCl |
Water Solubility | 13.4 mg/mL (25 oC) |
Merck | 14,9146 |
CAS DataBase Reference | 147127-20-6(CAS DataBase Reference) |
Items of analysis | Specification | Results |
Appearance | White powder or off-white powder | White Powder |
Identification | Must conform to reference standard | Conforms |
Water | NMT3.0% | 1.53% |
Residue on ignition | NMT2.0% | 1.07% |
Specific Rotation | -19.0°~-23.0° | -22.5° |
Sulphated ash | ≤1.5% | 0.27% |
Single impurity | ≤1.0% | 0.29% |
Total impurity | ≤3.0% | 1.11% |
Assay(Titrimetry) | 98.0%-102% | 99.60% |
9-Propenyl adenine | ≤100ppm | Conforms |
PMPA Monoester Impurity | ≤1.5% | 0.35% |
Conclusion | Qualified |
Tenofovir Usage And Synthesis
1. Antiviral drugs, Tenofovir is an acyclic nucleoside antiviral reverse transcriptase inhibitor. The active substance is Tenofovir disoproxil, while tenofovir is a prodrug that is used because of its better absorption in the gut.
2. Tenofovir can inhibit viral polymerase through direct competitively combine with natural deoxyribose or by insertion to terminate chain of human DNA. It is the first nucleotide analogs to treat HIV-1 infection that approved by the US Food and Drug Administration (FDA).
3. Tenofovir is a main medicine in AIDS cocktail therapy, researches has shown that it can effectively improve the monkeys` ability on prevention of immunodeficiency virus (similar to the human AIDS virus).
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- Since: 1996-07-16
- Address: Fujian China ,16F, Huicheng Comm. Complex, 839 Xiahe RD.