Tenofovir alafenamide fumarate NEW
| Price | $43 | $61 | $95 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-01 |
Product Details
| Product Name: Tenofovir alafenamide fumarate | CAS No.: 379270-38-9 |
| Purity: 99.95% | Supply Ability: 10g |
| Release date: 2024/11/01 |
Product Introduction
Bioactivity
| 名稱 | Tenofovir alafenamide fumarate |
| 描述 | Tenofovir alafenamide fumarate (GS-7340 fumarate) is an orally available precursor of Tenofovir with anti-HIV activity, used to prevent HIV infection. |
| 體外活性 | Tenofovir alafenamide fumarate antiviral activity was similar in all cell types, ranging from 5 to 7 nM, whereas CC50 varied from 4.7 to 42 μM for MT-4 and MT-2 cells. The antiviral activity of TAF was evaluated against a panel of HIV-1 and HIV-2 isolates, including HIV-1 M group subtypes A to G, as well as group N and O isolates. Overall, TAF EC50 ranged from 0.1 to 12 nM, with an average EC50 of 3.5 nM, compared to an average EC50 of 11.8 nM for AZT, used as an internal control, for 29 major HIV-1 isolates tested in PBMC. For HIV-2 isolates, the average EC50 is 1.8 nM for TAF and 6.4 nM for AZT.[2] |
| 體內(nèi)活性 | Tenofovir alafenamide fumarate (GS-7340 fumarate), an amidate prodrug of Tenofovir, exhibits enhanced oral bioavailability and plasma stability compared to Tenofovir disoproxil fumarate (TDF) [1]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : 25 mg/mL (42.19 mM), Sonication is recommended. DMSO : 200 mg/mL (337.53 mM), Sonication is recommended. |
| 關鍵字 | Tenofovir alafenamide Fumarate | GS-7340 Fumarate | GS7340 Fumarate | GS 7340 Fumarate |
| 相關產(chǎn)品 | Stavudine | 5-Fluorouracil | Emtricitabine | Kaempferol | Dolutegravir intermediate-1 | Dextran sulfate sodium salt (MW 4500-5500) | Lamivudine | Chloroquine phosphate | Decanedioic acid | Tenofovir |
| 相關庫 | FDA上市及藥典收錄分子庫 | 經(jīng)典已知活性庫 | 上市藥物庫 | EMA 上市藥物庫 | 藥物功能重定位化合物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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