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Postion:Product Catalog >TCMDC-135051
TCMDC-135051
  • TCMDC-135051

TCMDC-135051 NEW

Price $79 $196 $337
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-11

Product Details

Product Name: TCMDC-135051 CAS No.: 2413716-15-9
Purity: 98.21% Supply Ability: 10g
Release date: 2024/11/11

Product Introduction

Bioactivity

名稱TCMDC-135051
描述TCMDC-135051 is a potent and selective PfCLK3 protein kinase inhibitor demonstrating significant antiparasiticidal activity (EC50=320 nM) while exhibiting minimal off-target toxicity. It effectively hinders the transition from trophozoite to schizont, impairs transcription, and diminishes transmission to the mosquito vector.
體外活性In a liver invasion and development assay, TCMDC-135051 shows potent activity against P. berghei sporozoites in which the compound shows a pEC50 value of 6.17 (EC50=0.40 μM). The kinase assays using recombinant PvCLK3 (P. vivax) and PbCLK3 (P. berghei) show that TCMDC-135051 has near-equipotent inhibition at these two orthologs, with pIC50 values of 7.47 (IC50=0.033 μM) and 7.86 (IC50=0.013 μM), respectively[1].
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 225 mg/mL (477.1 mM), Sonication is recommended.
關(guān)鍵字TCMDC-135051 | TCMDC135051 | TCMDC 135051
相關(guān)庫高選擇性抑制劑庫 | 抗寄生蟲庫 | 經(jīng)典已知活性庫 | 抑制劑庫 | 已知活性化合物庫 | 抗感染化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

Recommended supplier

Product name Price   Suppliers Update time
$1980.00/50mg
VIP1Y
TargetMol Chemicals Inc.
2024-10-23
$122.00/1KG
VIP2Y
Henan Fengda Chemical Co., Ltd
2024-01-11
$79.00/1mg
VIP5Y
TargetMol Chemicals Inc.
2024-11-11
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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