Product Details
| Product Name:
Sulfoxaflor |
CAS No.:
946578-00-3 |
| Purity:
99.87% |
Supply Ability:
10g |
| Release date:
2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | Sulfoxaflor |
| 描述 | Sulfoxaflor (GF 2032) is an agonist of nAChR1 and nAChR2 subtypes and a systemic insecticide that acts on the insect central nervous system. Sulfoxaflor was found to have some effects on peripheral blood lymphocytes and is used to control sap-feeding insects such as brown planthopper, whitefly, peach aphid, and cotton aphid. |
| 體外活性 | METHODS: Blood lymphocytes were treated with Sulfoxaflor (GF 2032) (10 μg/mL, 20 μg/mL, 40 μg/mL), and single cell gel electrophoresis (comet electrophoresis), cytokinesis block micronucleus assay (MN assay), flow cytometry, and catalase (CAT) enzyme activity measurement were used to determine genotoxicity, apoptotic effects, and oxidative damage potential, respectively.
RESULTS CPBI values ??and the number of viable cells decreased; the number of late apoptotic and necrotic cells, micronucleus frequency, and comet assay parameters (GDI and DCP) increased; an increase in CAT enzyme levels was observed at 10 and 20 μg/mL concentrations, and CAT enzyme activity was inhibited at 40 μg/mL. [3] |
| 體內(nèi)活性 | METHODS: Sulfoxaflor (GF 2032) (25, 100, and 500 mg/kg, gavage, 4 weeks) was administered to rats and the relative testicular mass, testosterone, FSH, LH, MDA, and GPx levels, sperm motility, sperm morphology, sperm DNA damage, and histopathological changes in the testis, epididymis, and seminal vesicle were examined.
RESULTS Sulfoxaflor exposure resulted in an increase in FSH, LH, MDA, and GPx levels in sperm, as well as the percentage of dead and abnormal sperm and DNA damage in rat sperm. [2] |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 55 mg/mL (199.09 mM)
|
| 關鍵字 | Sulfoximine | Inhibitor | median | unpaired | insecticide | dorsal | XDE-208 | nAChR1 | GF-2372 | Sulfoxaflor | nAChR2 | GF-2032 | Nicotinic acetylcholine receptors | inhibit | XDE208 | nAChR | GF2372 | GF2032 |
| 相關產(chǎn)品 | Adiphenine hydrochloride | Nanofin | Arecoline hydrobromide | Forskolin | CLOZAPINE N-OXIDE | Pilocarpine nitrate | Ribavirin | Adenine | Choline chloride | Propoxur |
| 相關庫 | 農(nóng)藥化合物庫 | 疼痛相關化合物庫 | 神經(jīng)退行性疾病化合物庫 | 經(jīng)典已知活性庫 | 神經(jīng)信號分子庫 | 膜蛋白靶向化合物庫 | 神經(jīng)遞質(zhì)受體化合物庫 | 已知活性化合物庫 | 人代謝物化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$0.00/25kg |
VIP4Y
|
qingdao trust agri chemical co.,ltd
|
2024-08-16 |
United States