Sulforaphane NEW
| Price | $30 | $47 | $109 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-18 |
Product Details
| Product Name: Sulforaphane | CAS No.: 4478-93-7 |
| Purity: 99.79% | Supply Ability: 10g |
| Release date: 2024/11/18 |
Product Introduction
Bioactivity
| 名稱 | Sulforaphane |
| 描述 | Sulforaphane is a natural isothiocyanate that activates Nrf2 and inhibits AMPK-dependent signaling. Sulforaphane has antitumor and anti-inflammatory activities by increasing the transcription of tumor suppressor proteins and inhibiting histone deacetylase activity. |
| 細(xì)胞實驗 | HT29 cells are seeded at low density (5×10^4 cells/mL) in 35- or 120-mm diameter Primaria dishes in standard medium containing 5% FCS. One day after seeding, the medium is changed, and HT29 cells are treated with sulforaphane (0-30 μM). An equivalent amount of the solvent (ethanol) is added to control cells (0.2% final concentration). The drug effect on cellular viability is evaluated using the MTT assay [1]. |
| 動物實驗 | At age 47, 48, 49, 50, and 51 days, each animal receives by gavage either 0.5 mL of Emulphor EL-620 alone or the specified doses (75, 100, or 150 μM daily) of sulforaphane or compound 2, 3, or 4 in 0.5 mL of Emulphor EL-620. On day 50, 3 hr after administration of the vehicle or protector, all rats also receive an intragastric instillation of 8.0 mg of DMBA dissolved in 1.0 mL of sesame oil. This dose of DMBA is selected to produce a substantial tumor incidence, but not one so high as to overwhelm a potential chemoprotective effect. The animals are examined once weekly for the appearance and location of palpable tumors. At age 202 days, i.e., 152 days after carcinogen administration, all animals are euthanized with ether and weighed. The tumors are separated from the fat and connective tissue by dissection weighed and fixed in buffered 10% formalin. All tumors are identified microscopically by examination of stained sections [3]. |
| 體外活性 | METHODS: Human colorectal cancer cells HT29 were treated with Sulforaphane (15 μM) for 24-96 h. Cell viability was measured by MTT assay. RESULTS: Sulforaphane at 15 μM was able to inhibit cell growth and induce cell death. 75% of the cells were already dead at 24 h, and almost all of them were dead at 96 h. [1] METHODS: Gastric cancer cells BGC-823 and MGC-803 were treated with Sulforaphane (5-10 μM) for 48 h. The expression levels of target proteins were measured by Western Blot. RESULTS: When gastric cancer cells were treated with Sulforaphane, the expression levels of cell cycle regulatory proteins such as p53 and p21 were increased in a dose-dependent manner, whereas the expression level of S-phase related protein CDK2 was significantly decreased. [2] |
| 體內(nèi)活性 | METHODS: To test the anti-inflammatory activity, a single dose of Sulforaphane (50 mg/kg) was administered intraperitoneally to BALB/c mice. Three days later, LPS was injected to induce acute lung injury (ALI). RESULTS: Sulforaphane significantly reduced LDH activity, lung wet-to-dry ratio, serum IL-6 and TNF-α levels, and NF-κB protein expression in mice with LPS-induced acute lung injury.Sulforaphane exerted its protective effect on LPS-induced ALI through the Nrf2/ARE pathway. [3] |
| 存儲條件 | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 55 mg/mL (310.23 mM) |
| 關(guān)鍵字 | Keap1-Nrf2 | inhibit | Inhibitor | HDAC | Histone deacetylases | Apoptosis | Sulforaphane |
| 相關(guān)產(chǎn)品 | Stavudine | 5-Fluorouracil | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Metronidazole | Tributyrin | Curcumin |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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