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Postion:Product Catalog >SU0268
SU0268
  • SU0268

SU0268 NEW

Price $41 $97 $155
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-13

Product Details

Product Name: SU0268 CAS No.: 2210228-45-6
Purity: 99.98% Supply Ability: 10g
Release date: 2024/11/13

Product Introduction

Bioactivity

名稱SU0268
描述SU0268 is a potent and specific 8-Oxoguanine DNA glycosylase 1 (OGG1) inhibitor that regulates inflammatory responses during Pseudomonas aeruginosa infection.
體外活性SU0268/IACS-4759 (5-20 μM, 48h) co-treated cells are more viable than the correspondingly-treated IACS-4759- or SU0268-treated cells[1]. MTH1-depleted cells are less sensitive to the OGG1-specific inhibitor, SU0268 (5-10 μM), compared to their control shGFP counterparts[1]. SU0268 does not bind DNA and thus interacts with OGG1 specifically rather than its substrate[2]. SU0268 induces the release of type I IFN by the mitochondrial DNA-cGAS-STING-IRF3-IFN-β axis, which decreases bacterial loads and halts disease progression[3].
體內(nèi)活性In MH-S cells and C57BL/6N mice, SU0268 pretreatment (10 mg/kg, intranasally treated) increases survival rates compared with controls without SU0268 pretreatment [3].
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 100 mg/mL (210.28 mM), Sonication is recommended.
關鍵字MCF-7 | Inhibitor | cGAS | OGG1 | A549 | STING | SU 0268 | IRF3 | SU-0268 | inhibit | HeLa | glycosylase | antibacterial | SU0268
相關庫DNA 損傷和修復分子庫 | 經(jīng)典已知活性庫 | 抑制劑庫 | NO PAINS 化合物庫 | 已知活性化合物庫 | 抗感染化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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