SSR504734 HCl NEW
| Price | $68 | $163 | $263 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: SSR504734 HCl | CAS No.: 615571-23-8 |
| Purity: 99.54% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | SSR504734 HCl |
| Description | SSR504734 is an orally active, selective, and reversible inhibitor of human, rat, and mouse GlyT1 (IC50 = 18, 15, and 38 nM, respectively). SSR504734 exhibits activity in schizophrenia, anxiety, and depression models [1]. |
| In vitro | SSR504734 (15 nM-86 μM; 10 min) inhibits the ex vivo uptake of glycine in human SK-N-MC and rat C6 cells, with IC50 values of 18 nM and 15 nM, respectively [1]. |
| In vivo | SSR504734 (i.p. and p.o.; 1-100 mg/kg; once) demonstrates good oral bioavailability with ID50 values of 5.0 and 4.6 mg/kg for i.p. and p.o. treatments, respectively [1]. At 30 mg/kg (i.p.; once), it maintains approximately 80% inhibition of specific glycine uptake from 1 to 7 hours post-administration [1]. At 10 mg/kg (i.p.; once), it rapidly and significantly increases extracellular glycine levels in the prefrontal cortex of freely moving male Sprague-Dawley rats [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | Compound 1549 | SSR504734 HCl |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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