Description: 

Spironolactone is a potassium-sparing diuretic that is primarily used to treat a variety of conditions related to heart, liver, kidneys, and hormonal imbalances. Its main uses include: 

1. Heart Failure: Spironolactone is used to manage symptoms of heart failure, such as swelling and difficulty breathing, by reducing fluid buildup in the body. It can improve survival rates and reduce the need for hospitalization in patients with severe heart failure. 

2. Hypertension (High Blood Pressure): It can be used alone or in combination with other medications to treat high blood pressure, which helps prevent strokes, heart attacks, and kidney problems. 

3. Primary Hyperaldosteronism: This condition is characterized by the overproduction of aldosterone by the adrenal glands, leading to high blood pressure and low potassium levels. Spironolactone is used as a diagnostic tool and a long-term treatment for primary hyperaldosteronism. 

4. Edema (Fluid Retention): It is effective in treating edema associated with liver cirrhosis, nephrotic syndrome (a kidney disorder), and heart failure. Spironolactone helps reduce the swelling and fluid retention without causing the loss of potassium from the body. 

5. Polycystic Ovary Syndrome (PCOS): Spironolactone can be used off-label to treat certain symptoms of PCOS, such as hirsutism (excessive hair growth) and acne, due to its anti-androgen effects. 

6. Acne and Seborrhea: Due to its anti-androgen properties, spironolactone can be used off-label to treat acne and seborrhea in women, especially when these conditions are resistant to other treatments. 

7. Female Pattern Hair Loss: It may also be used off-label to treat female pattern hair loss, again because of its ability to inhibit the effects of androgens on the scalp.

Synonym: Aldactone, Spirolactone, Verospirone, Euteberol, Verospiron, Spirolang, Acelat, Spironocompren, Aldactone A, Aquareduc, Spirobeta, Spirogamma

Molecular Formula: C24H32O4S

Molecular Weight: 416.58 g/mol

Appearance: Solid powder

Purity: 97.00~103.00%

Melting Point: 207-208 °C (lit.)

Boiling Point: 504.87°C (rough estimate)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Keep container tightly closed in a dry and well-ventilaed place.

Solubility: Very soluble in trichloromethane,Freely soluble inbenzane or ethyl acetate,soluble in alcohol,Practicallyinsoluble in water.

Shelf Life: >2 years if stored properly

HS Tariff Code: 2932209090

More Info: Spironolactone is a mild potassium-sparing diuretic. Its chemical structure is similar to aldosterone. It competes with aldosterone for aldosterone receptors in the distal convoluted tubule and collecting duct cells, affecting the binding of aldosterone to its receptor. This interference hinders the synthesis of aldosterone-induced proteins, thus inhibiting K+-Na+ exchange, reducing the excretion of potassium, and producing a potassium-sparing diuretic effect.