Spermidine NEW
| Price | $45 |
| Package | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-18 |
Product Details
| Product Name: Spermidine | CAS No.: 124-20-9 |
| Purity: 99.73% | Supply Ability: 10g |
| Release date: 2024/11/18 |
Product Introduction
Bioactivity
| 名稱 | Spermidine |
| 描述 | Spermidine (N-(3-Aminopropyl)-1,4-diaminobutane) inhibits NOS1 (nNOS). Spermidine binds and precipitates DNA and may be used for purification of DNA binding proteins. Spermidine activates PNK (polynucleotide kinase T4). Spermidine binds to and activates NMDA and has been shown to potentiate NMDA-induced currents in a concentration-dependent manner. |
| 體外活性 | METHODS: Human neuroblastoma cells SH-SY5Y were treated with Spermidine (0.05-10 μM) for 24-48 h. Mitochondrial metabolic activity was measured by MTT assay and ATP production assay. RESULTS: No effect of Spermidine was observed after 24 h. 0.1 and 1 μM Spermidine significantly increased cellular metabolic activity and ATP production after 48 h of treatment. The most effective concentration of Spermidine, 0.1 μM, induced an 8.2% increase in metabolic activity and a 4% increase in ATP production. [1] METHODS: The retinal pigment epithelial cell line ARPE-19 was treated with H2O2 (300 μM) and Spermidine (10 μM) for 24 h. Apoptosis was detected by Flow cytometry. RESULTS: 300 μM H2O2 significantly increased the frequency of annexin V-positive cells to approximately 25%, but Spermidine significantly inhibited this increase. The results suggest that Spermidine attenuates H2O2-mediated oxidative stress-induced apoptosis in ARPE-19 cells. [2] |
| 體內(nèi)活性 | METHODS: To study the effects on diabetes, Spermidine (10 mM) was administered orally in water to non-obese diabetic (NOD) mice (type 1 diabetes mouse model) for thirty weeks. RESULTS: Treatment of NOD mice with Spermidine resulted in a higher incidence of diabetes, although pancreatic insulitis was not altered.Spermidine modulated pancreatic tissue polyamine levels and increased signs of autophagy.Spermidine resulted in an increase in the proportion of pro-inflammatory T-cells in the pancreatic lymph nodes (pLN) of diabetic mice. [3] |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | 5% DMSO+95% Saline : 1.67 mg/mL (11.5 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. DMSO : 33.33 mg/mL (229.47 mM), Sonication is recommended. H2O : 100 mg/mL (688.47 mM), Sonication is recommended. |
| 關(guān)鍵字 | photosystem | membrane | inhibit | stability | PSII | Inhibitor | cell | Endogenous Metabolite | H2O2 | Spermidine |
| 相關(guān)庫 | 中藥單體化合物庫 | 經(jīng)典已知活性庫 | 中藥抗炎分子庫 | 天然產(chǎn)物庫 | 煙草單體化合物庫 | 微生物天然產(chǎn)物庫 | 高通量篩選天然產(chǎn)物庫 | 化妝品成分化合物庫 | 人內(nèi)源代謝化合物庫 | 腸道微生物代謝化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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