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Postion:Product Catalog >SP-141
SP-141
  • SP-141

SP-141 NEW

Price $38 $85 $130
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: SP-141 CAS No.: 1253491-42-7
Purity: 98.01% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameSP-141
DescriptionSP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.
In vitroSP141, which bound directly to MDM2, promoting its auto-ubiquitination and degradation by the proteasome.?The compound reduced levels of MDM2 in pancreatic cancer cell lines, as well as their proliferation, with 50% inhibitory concentrations <0.5 μM (0.38-0.50 μM).?Increasing concentrations of SP141 induced increasing levels of apoptosis and G2-M-phase arrest of pancreatic cancer cell lines, whether or not they expressed functional P53[1].
In vivoInjection of nude mice with SP141 (40 mg/kg/d) inhibited growth of xenograft tumors (by 75% compared with control mice), and led to regression of orthotopic tumors[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 4.4 mg/mL (13.56 mM)
Keywordspancreatic | inhibit | Inhibitor | cancer | MDM-2/p53 | breast | degradation | SP-141 | SP141 | auto-ubiquitination
Inhibitors RelatedMilademetan | Alrizomadlin | MMRi64 | Serdemetan | XI-006 | RG7112 | RDR03871 | SAR405838 | Idasanutlin | Navtemadlin | RO-5963 | RITA
Related Compound LibrariesApoptosis Compound Library | Anti-Lung Cancer Compound Library | Bioactive Compound Library | Pyroptosis Compound Library | Inhibitor Library | PPI Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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