Product Details
Product Name:
Soticlestat |
CAS No.:
1429505-03-2 |
Purity:
99.95% |
Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
Name | Soticlestat |
Description | Soticlestat (OV935) is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor. It has the potential for epilepsy syndromes research. |
In vitro | Soticlestat inhibits the catalytic activity of human cholesterol 24-hydroxylase (CH24H) in a concentration-dependent manner with an IC50?of 4.5 nM |
In vivo | Soticlestat treatment lowers brain 24S-hydroxycholesterol in a dose-dependent manner and substantially reduceds premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%. Soticlestat can suppress potassium-evoked extracellular glutamate elevations in the hippocampus |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 100 mg/mL (267.77 mM), Sonication is recommended.
|
Keywords | Inhibitor | CYP46A1 | inhibit | TAK935 | cholesterol | 24-hydroxylase | NMDA | antiepileptic | OV 935 | CYPs | epilepsy | TAK 935 | OV-935 | Soticlestat | Cytochrome P450 |
Inhibitors Related | Tebuconazole | 1-Ethynylnaphthalene | Diflubenzuron | Apigenin | Gemfibrozil | Fenofibrate | 1-Aminobenzotriazole | Methoxsalen | Naringin | Naringenin | Tauroursodeoxycholate | Doxepin hydrochloride |
Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Pediatric Drug Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Orally Active Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |