Sofalcone NEW
| Price | $48 | $81 |
| Package | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-11 |
Product Details
| Product Name: Sofalcone | CAS No.: 64506-49-6 |
| Purity: 99.40% | Supply Ability: 10g |
| Release date: 2024/11/11 |
Product Introduction
Bioactivity
| 名稱 | Sofalcone |
| 描述 | Sofalcone (SU-88), a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium. |
| 細(xì)胞實驗 | Primary HUVECs are seeded at 60?000 cells per well and incubated at 37°C for 14 to 16 hours to allow tube formation. Cells are then cultured in the presence of either TNF-α (10 ng/mL) alone, with both TNF-α (10 ng/mL) and Sofalcone 50 μM, or control media for 8 to 12 hours. Tube formation is assessed, and images are captured using microscope at ×4 magnification. |
| 體外活性 | Sofalcone (50 μmol/L) significantly enhances HO-1 mRNA and protein expression in both trophoblasts and primary human umbilical vein endothelial cells (HUVECs), evidenced by Western blot analyses and comparison with control groups (P<0.05). It also boosts Nrf2 presence in HUVEC nuclear fractions after 6 hours and upregulates NQO1, TXN, and GCLC expression in primary HUVECs dose-dependently over 24 hours. Additionally, Sofalcone markedly reduces sFlt-1 concentrations in culture media and decreases THP-1 monocyte adherence to HUVECs in a dose-dependent manner, underscoring its potential therapeutic implications for vascular health. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (110.98 mM) |
| 關(guān)鍵字 | inhibit | Sofalcone | Bacterial | SU88 | SU 88 | Inhibitor | Autophagy |
| 相關(guān)產(chǎn)品 | Neomycin sulfate | Stavudine | Ampicillin sodium | Kanamycin sulfate | Sulfamethoxazole sodium | Hydroxychloroquine | Guanidine hydrochloride | Doxycycline | Paeonol | Naringin | Dimethyl sulfoxide | Salicylic acid |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 藥物功能重定位化合物庫 | 抗癌上市藥物庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 抗癌藥物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $0.00/1kg |
VIP4Y
|
Sinoway Industrial co., ltd.
|
2024-05-20 | |
| $100.00/1kg |
Hebei Shengyuan Jinlong Import and Export Co. LTD
|
2022-10-28 | ||
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-08-10 | ||
| $0.00/20KG |
Qiuxian Baitai New Material Co., LTD
|
2021-03-16 | ||
| $10.00/1KG |
Handan Tongyi New Material Technology Co., Ltd
|
2021-03-10 | ||
| $0.00/1KG |
hdzhl biotechnology co., ltd
|
2019-09-09 | ||
| $1.00/1KG |
VIP7Y
|
Career Henan Chemical Co
|
2018-12-24 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY