Sodium dichloroacetate NEW
| Price | $45 |
| Package | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-17 |
Product Details
| Product Name: Sodium dichloroacetate | CAS No.: 2156-56-1 |
| Purity: 99.87% | Supply Ability: 10g |
| Release date: 2024/11/17 |
Product Introduction
Bioactivity
| 名稱(chēng) | Sodium dichloroacetate |
| 描述 | Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion channel axis, trigger apoptosis in cancer cells, and inhibit tumor growth. |
| 體外活性 | METHODS: Tumor cells A549, MO59K and MCF-7 and normal cells SAEC were treated with Sodium dichloroacetate (0.5 mM) for 48 h. Mitochondrial membrane potential ΔΨm was detected using fluorescent dye. RESULTS: Incubation of all three types of tumor cells with Sodium dichloroacetate reversed hyperpolarization and restored ΔΨm to the level of normal cells. In contrast, Sodium dichloroacetate did not alter ΔΨm in SAEC. [1] METHODS: OSCC cell lines HSC-2, HSC-3 and PE15 were treated with Sodium dichloroacetate (1-10 mM) for 24 h. Cell viability was measured using the MST assay. RESULTS: HSC-2 and HSC-3 showed more significant unique sensitivity to the drugs. Compared with HEK 293, the viability of both HSC-2 and HSC-3 was about 30% at 10 mM Sodium dichloroacetate, while the viability of PE15 was 75-80%. [2] |
| 體內(nèi)活性 | METHODS: To study the effect on energy expenditure in ApoE-/- mice, Sodium dichloroacetate (100-150 mg/kg) was administered by gavage once daily for four weeks to ApoE-/- mice fed the western diet model of atherosclerosis. RESULTS: Western diet-fed ApoE-/- mice developed atherosclerotic plaques and hyperlipidemia, as well as obesity, which were significantly ameliorated by the administration of Sodium dichloroacetate. Enhanced glucose oxidation by Sodium dichloroacetate protects against atherosclerosis by inducing hepatic FGF21 expression and BAT activation, thereby increasing the risk of atherosclerosis. atherosclerosis, thereby increasing energy expenditure for calorie production. [3] |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : 166.66 mg/mL (1104.3 mM), Sonication is recommended. DMSO : 50 mg/mL (331.3 mM) |
| 關(guān)鍵字 | lactic | pyruvate | PDH kinase | ROS | Reactive Oxygen Species | acid | mitochondria | PDHK | Anticancer | inhibit | NKCC | metabolic | Sodium dichloroacetate | Apoptosis | dehydrogenase | Inhibitor | Pyruvate dehydrogenase kinase |
| 相關(guān)庫(kù) | 抗癌天然產(chǎn)物庫(kù) | 激酶抑制劑庫(kù) | 抗癌臨床化合物庫(kù) | 藥物功能重定位化合物庫(kù) | 天然產(chǎn)物庫(kù) | 抑制劑庫(kù) | 高通量篩選天然產(chǎn)物庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) | 抗癌藥物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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