SK1- I hydrochloride NEW
| Price | $332 |
| Package | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: SK1- I hydrochloride | CAS No.: 2366222-05-9 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | SK1- I hydrochloride |
| Description | SK1-I hydrochloride (BML-258 hydrochloride) is a sphingosine analog that enhances autophagy and exhibits antitumor activity. This isozyme-specific competitive SPHK1 inhibitor has a Ki value of 10 μM [1] [2]. |
| In vitro | SK1-I hydrochloride (0-10 μM; 24 hours) reduces cancer cell growth and survival in a TP53-dependent manner in HCT116 cells and TP53-null HCT116 cells. Additionally, SK1-I hydrochloride (0-20 μM; 12 hours) increases CASP3 cleavage in TP53-expressing HCT116 cells, indicating apoptosis. [Cell Viability Assay: HCT116 cells and TP53-null HCT116 cells; 0, 2.5, 5, 7.5, 10 μM; 24 hours. Result: Decreased cell growth and survival. Western Blot Analysis: HCT116 cells and TP53-null HCT116 cells; 0, 5, 10, 20 μM; 12 hours. Result: Increased CASP3 cleavage]. |
| In vivo | Pre-treatment with SK1-I hydrochloride (also known as BML-258 hydrochloride) via intraperitoneal (i.p.) injection at 75 mg/kg, administered 24 hours before baseline mean arterial blood pressure (MAP) measurement, significantly reduces the hypotensive effect of subsequent anandamide administration (i.v. injection at 1 and 10 mg/kg). This was observed in male C57BL/6 mice weighing 24 ± 3.5 g. The regimen highlights the drug's impact on blood pressure modulation and demonstrates a marked decrease in baseline MAP, suggesting a notable interaction between SK1-I hydrochloride and anandamide in vascular responses. |
| Storage | Shipping with blue ice. |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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