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SJ-172550 NEW
Price | $37 | $59 | $97 |
Package | 2mg | 5mg | 10mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-19 |
Product Details
Product Name: SJ-172550 | CAS No.: 431979-47-4 |
Purity: 99.87% | Supply Ability: 10g |
Release date: 2024/11/19 |
Product Introduction
Bioactivity
Name | SJ-172550 |
Description | SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM). |
In vitro | SJ-172550 interacts with the p53-binding pocket of MDMX, effectively displacing p53 and reversibly binding to MDMX, resulting in the death of retinoblastoma cells with amplified MDMX expression. This compound establishes a covalent, yet reversible, complex with MDMX, which prohibits MDMX from binding to p53. The efficacy of SJ-172550 is enhanced when used in conjunction with the MDM2 inhibitor, nutlin-3a. The stability of the SJ-172550/MDMX complex is dependent on several factors, such as the media's reducing potential and the presence of aggregates. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 33.33 mg/mL (77.72 mM), Sonication is recommended. |
Keywords | E3 ligating enzyme | Ubiquitin activating enzyme | E2 conjugating enzyme | E1/E2/E3 Enzyme | MDM-2/p53 | Ubiquitin ligase | E1 activating enzyme | SJ 172550 | SJ-172550 | inhibit | Ubiquitin conjugating enzyme | Inhibitor | SJ172550 |
Inhibitors Related | Milademetan | NSC697923 | XI-006 | PYZD-4409 | Nutlin-3 | NAcM-OPT | PYR-41 | NSC232003 | NAE-IN-M22 | Indole-3-carbinol | Idasanutlin | RITA |
Related Compound Libraries | Anti-Colorectal Cancer Compound Library | Apoptosis Compound Library | Anti-Lung Cancer Compound Library | Bioactive Compound Library | Anti-Cancer Metabolism Compound Library | Inhibitor Library | PPI Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Transcription Factor-Targeted Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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ShenZhen H&D Pharmaceutical Technology Co., LTD
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2024-07-11 |
- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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