Sirt1/2-IN-2 NEW
| Price | Get Latest Price | |
| Package | 5mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-27 |
Product Details
| Product Name: Sirt1/2-IN-2 | CAS No.: 670267-73-9 |
| Supply Ability: 10g | Release date: 2025/04/27 |
Product Introduction
Bioactivity
| Name | Sirt1/2-IN-2 |
| Description | Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor, targeting SIRT1 with an IC50 of 1.8 μM and SIRT2 with an IC50 of 2.4 μM. It effectively inhibits p53 deacetylation while enhancing the acetylation of p53 and α-tubulin, promoting apoptosis and exhibiting anti-proliferative effects on human leukemia cell lines [1]. |
| In vitro | Sirt1/2-IN-2 (compound hsa55) induces apoptosis in various tumor cell lines at 5 μM over 48 hours, with IC50 values of 13 μM for MV4-11, 11.5 μM for MOLM-13, 34.4 μM for THP1, and 27.5 μM for Jurkat cells [1]. At 100 μM for 30 minutes, it reduces the thermal stability of SIRT1 and SIRT2 proteins at different temperatures. At 25 μM and 30 μM over 24 hours, the compound increases acetylated p53 and α-tubulin levels in MOLM-13 cells [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Inhibitors Related | JGB1741 | Sirtinol | Selisistat | Nicotinamide riboside chloride | Dihydrocoumarin | Resveratrol | SRT 2104 | Nicotinamide riboside | MC3482 | Fisetin | 3-TYP | Nicotinamide |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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