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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Neuronal Signaling>Adrenergic Receptor Antagonists>Silodosin
Silodosin
  • Silodosin
  • Silodosin
  • Silodosin
  • Silodosin
  • Silodosin

Silodosin NEW

Price Get Latest Price
Package 1kg
Min. Order: 1kg
Supply Ability: 10000kg
Update Time: 2024-04-13

Product Details

Product Name: Silodosin CAS No.: 160970-54-7
EC-No.: 814-909-2 Min. Order: 1kg
Purity: 99% Supply Ability: 10000kg
Release date: 2024/04/13

Manufacturer ProvidRaw Material 99% Bulk CAS 160970-54-7 Silodosin Powder

Article illustration

Introduction

Product Name: Silodosin

Other Name :Silodosin-d4;Silodoxin;1H-Indole-7-carboxaMide,2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]aMino]propyl]

CAS NO:160970-54-7

Purity: 99%min
Appearance:White crystalline powder

Molecular formula:C25H32F3N3O4

MW:495.53

Melting Pint :>104°C (dec.)

Boiling Point :601.4±55.0 °C(Predicted)

Density:1.249±0.06 g/cm3(Predicted)

Storage :Keep in dark place,Inert atmosphere,Room temperature


Silodosin is an alpha-adrenergic receptor antagonist invented by Kissei Pharmaceutical Company in Japan, which has a very good effect on the treatment of urinary disorders associated with benign prostatic hyperplasia. The selective effect on urethra was 12 and 7.5 times higher than prazosin and Tamsulosin, respectively, and could significantly inhibit the prostate contraction induced by norepinephrine. It can inhibit bladder hyperactivity in a dose-dependent manner and increase the pressure threshold of bladder contraction in benign prostatic hypertrophy rats. These data suggest that cilodoxine, in addition to improving bladder function, is also effective in alleviating symptoms associated with benign prostatic hypertrophy. Compared to its peers Prazosin and Tamsulosin, silodoxin is highly selective towards α1A-receptors located in the prostate and bladder neck, while its affinity for α1B- and α1D- receptors is not significant. It blocks the alpha1A-receptor at this site, relaxes smooth muscle, and leads to improved urine flow and reduced BPH symptoms. Silodoxin binds more selectively to the α1A-receptor than to the cardiovasculary-associated α1b-receptor, maximizing activity to the target organ while minimizing potential effects on blood pressure.


Fuction and Application of Silodosin
1 Silodosin Got a good solve the curative effect of dysuria, also reduced the incidence of hypotension and other adverse reactions.
2 Silodosin can reduce peripheral vascular resistance in other parts of the body to the body of the systolic blood pressure and diastolic pressure is lower.


Article illustration


Company Profile Introduction

Shaanxi TNJONE Pharmaceutical Co., Ltd supplies more than 2,000 kinds of products, covering the whole field of health industry, including human APIs, veterinary APIs, food additives, natural nutrition ingredients, feed additives, cosmetic additives, intermediates etc. With global sourcing advantages, the group is fully capable of meeting the one-stop sourcing needs of global customers. Today, Shaanxi TNJONE Pharmaceutical Co., Ltd.'s marketing network has spread over more than 100 countries and regions on five continents, providing professional service for global customers.

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Shaanxi TNJONE Pharmaceutical Co., Ltd

1YR ChinaChina
  • Since: 2019-05-23
  • Address: No. 4C-11-A392, Financial Port, Northwest corner of Fengjing Avenue and Fengxin Road, Fengdong New C
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