SHP099 hydrochloride NEW
| Price | $32 | $71 | $98 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: SHP099 hydrochloride | CAS No.: 2200214-93-1 |
| Purity: 99.62% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | SHP099 hydrochloride |
| 描述 | SHP099 hydrochloride is a potent, selective, orally bioavailable SHP2 inhibitor with IC50 of 70 nM, which inhibits ERK1/2 activation in cancer cells. [2] |
| 細胞實驗 | Cells are plated onto 96-well plates in 100 μL medium. SHP099 with various concentrations (1.25, 2.5, 5, 10, 20 μM) are added 24 h after cell plating. At day 5, 50 μL Celltiter-Glo reagent is added, and the luminescent signal is determined[1]. |
| 激酶實驗 | The inhibition of SHP2 from the tested compounds (SHP099) concentrations varying from 0.003-100 μM is monitored using an assay in which 0.5 nM of SHP2 is incubated with of 0.5 μM of peptide IRS1_pY1172(dPEG8)pY1222. After 30-60 minutes incubation at the surrogate substrate, DiFMUP is added to the reaction and incubated at 25 °C for 30 minutes. The reaction is then quenched by the addition of 5 μL of a 160 μM solution of bpV(Phen). The fluorescence signal is monitored using a microplate reader using excitation and emission wavelengths of 340 nm and 450 nm, respectively[1]. |
| 體外活性 | METHODS: Cell viability of SMSCs was observed after treatment with different concentrations of SHP099 (5, 10, 15, 20, 25, 30, 40, 50 μM) for 1 week. RESULTS SHP099 inhibited the cell viability of SMSCs at concentrations greater than 25 μM. [2] |
| 體內(nèi)活性 | METHODS: The imiquimod (IMQ)-induced mouse psoriasis model was treated with SHP0999 (1, 3, 10 mg/kg), and the effect of SHP099 on the psoriasis-like phenotype in the IMQ-induced mouse model was observed. . RESULTS SHP099 significantly inhibited IMQ-induced swelling, epidermal acanthosis, keratinocyte proliferation and dermal inflammatory cell infiltration without affecting the skin condition of normal mice; SHP099 also significantly reduced serum IL-23 and IL in the mouse model -17A level. [1] METHODS: The ability of SHP099 to cross the BBB in C57BL/6J mice was evaluated after a single oral dose of SHP099 at 100 mg/kg in a 400 μL volume. RESULTS SHP099 concentrations were high in plasma and brain tissue early after oral gavage, and SHP099 levels in brain tissue remained at appreciable levels 24 h after oral gavage. [2] METHODS: CT-26 and MC-38 cells were subcutaneously inoculated into BALB/c mice to establish a mouse tumor model. The mouse tumor model used SHP099 hydrochloride (5 mg/kg/kg/d, intraperitoneal injection). SHP099 salt was observed. Effects of salt on tumors. RESULTS The volume and weight of tumors treated with SHP099 were significantly reduced. [3] |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Methanol : 15 mg/mL (38.59 mM), Sonication is recommended. DMSO : 55 mg/mL (141.49 mM), Sonication and heating are recommended. H2O : 10 mg/mL (25.73 mM), Sonication is recommended. |
| 關(guān)鍵字 | SHP-099 | SHP099 Hydrochloride | SHP 099 | SHP099 hydrochloride | Inhibitor | SHP 099 Hydrochloride | Phosphatase | inhibit | SHP-099 Hydrochloride | SHP-099 hydrochloride | SHP099 |
| 相關(guān)產(chǎn)品 | PTP1B-IN-22 | Disodium monofluorophosphate | β-Glycerophosphate disodium salt pentahydrate | MLS000544460 | Tartaric acid disodium dihydrate | Cyclosporine | Stearic acid | Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride | L-Ascorbic acid 2-phosphate magnesium | Cyclosporin A | Trimyristin | β-Glycerophosphate disodium salt hydrate |
| 相關(guān)庫 | 高選擇性抑制劑庫 | 糖代謝化合物庫 | 經(jīng)典已知活性庫 | 自噬庫 | 抑制劑庫 | NO PAINS 化合物庫 | 脂代謝化合物庫 | 已知活性化合物庫 | 臨床前化合物庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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