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Postion:Product Catalog >SGC-AAK1-1
SGC-AAK1-1
  • SGC-AAK1-1

SGC-AAK1-1 NEW

Price $38 $73 $148
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-15

Product Details

Product Name: SGC-AAK1-1 CAS No.: 2247894-32-0
Purity: 99.65% Supply Ability: 10g
Release date: 2024/11/15

Product Introduction

Bioactivity

名稱SGC-AAK1-1
描述SGC-AAK1-1, a potent and selective inhibitor of AAK1 (AP2-associated kinase 1), has an IC50 of 270 nM and a Ki of 9 nM, and serves as a chemical probe.
體外活性phosphorylation of AP2M1 (T156)significantly reduced by SGC-AAK1-1 (1.25 μM) and activates WNT-driven BAR activity compared in a dose-dependent manner in HT1080 cells. SGC-AAK1-1 blocks AAK1 kinase activity, resulting in increased β-catenin protein stability and β-catenin-dependent transcription.
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 40 mg/mL (93.56 mM), Sonication and heating to 60℃ are recommended.
關(guān)鍵字AAK1 | BMP2K | pathway | kinase | Inhibitor | inhibit | associated | SGCAAK11 | Wnt | SGC-AAK-1-1 | AP2 | SGC AAK1 1 | SGC-AAK1-1
相關(guān)產(chǎn)品RSS0680 | LP-922761 | SM1-71 | (Iso)-BMT-124110 Formate | BMT-124110 | BMS-986176 | BMT-124110 Formate | LP-935509
相關(guān)庫神經(jīng)退行性疾病化合物庫 | 經(jīng)典已知活性庫 | 神經(jīng)信號(hào)分子庫 | 激酶抑制劑庫 | 抑制劑庫 | NO PAINS 化合物庫 | 已知活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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