Scutellarin NEW
| Price | $45 | $77 | $134 |
| Package | 10mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-18 |
Product Details
| Product Name: Scutellarin | CAS No.: 27740-01-8 |
| Purity: 99.32% | Supply Ability: 10g |
| Release date: 2024/11/18 |
Product Introduction
Bioactivity
| Name | Scutellarin |
| Description | Scutellarin (Scutellarein-7-glucuronide), an active flavone isolated from Scutellaria baicalensis, can inhibit RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts, and down-regulate the STAT3/Girdin/Akt signaling in HCC cells. |
| Cell Research | HepG2 cells (1×105/well) are cultured in 96-well plates and treated in triplicate with scutellarin at concentrations of 5, 10, 20, 30, and 100 μM or vehicle alone for 24 h. The cellular viability is tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and is expressed as a percentage of proliferation versus controls. |
| In vitro | Scutellarin significantly lowers HepG2 cell viability in a dose-dependent manner and hampers HCC cells' migration and invasion in vitro. It notably decreases STAT3 and Girdin expression, along with the phosphorylation of STAT3 and Akt in HCC cells. The overexpression of STAT3 reverses the suppression by scutellarin of Girdin expression and Akt activation, restoring HCC cells' ability to migrate and invade. Furthermore, overexpression of Girdin nullifies scutellarin's inhibitory effects on Akt phosphorylation, and on the migration and invasion of HCC cells. Scutellarin can prevent HCC cell metastasis in vivo and restrict their migration and invasion in vitro by targeting the STAT3/Girdin/Akt pathway. Additionally, scutellarin has a neuroprotective role by inhibiting microglial activation, mitigating neuroinflammation, and promoting astrocytic response by upregulating neurotrophic factor expression. This demonstrates a beneficial interaction between activated microglia and astrocytes. Scutellarin also impedes RANKL-mediated osteoclastogenesis and bone resorption by reducing osteoclast-specific gene expression (TRAP, cathepsin K, c-Fos, NFATc1) and inhibiting the RANKL-mediated MAPK and NF-κB signaling pathways, including JNK1/2, p38, ERK1/2, and IκBα phosphorylation. |
| In vivo | Scutellarin administration at a dosage of 50 mg/kg/day notably reduces both lung and intrahepatic metastasis of HCC tumors in vivo. Comparatively, the scutellarin-treated group exhibits a significant decrease in the number of metastatic tumors in the lung and liver versus the control group[1]. Furthermore, rats receiving Scutellarin show marked improvement in neurobehavioral deficits in contrast to the SAH group, alongside an enhancement in eNOS expression[4]. |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (108.14 mM) H2O : insoluble |
| Keywords | PKB | Inhibitor | inhibit | HIV | Protein kinase B | Human immunodeficiency virus | Akt | Scutellarin | STAT |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Emtricitabine | Kaempferol | Dolutegravir intermediate-1 | Dextran sulfate sodium salt (MW 4500-5500) | Lamivudine | Decanedioic acid | 2,3-Butanediol | Tenofovir |
| Related Compound Libraries | 抗癌天然產(chǎn)物庫 | 黃酮類天然產(chǎn)物庫 | 中藥單體化合物庫 | 激酶抑制劑庫 | 天然產(chǎn)物庫 | 抑制劑庫 | 高通量篩選天然產(chǎn)物庫 | 抗病毒中藥單體化合物庫 | 已知活性化合物庫 | 古代經(jīng)典名方目錄分子庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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