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Postion:Product Catalog >SBI-0206965
SBI-0206965
  • SBI-0206965

SBI-0206965 NEW

Price $38 $61 $101
Package 2mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-13

Product Details

Product Name: SBI-0206965 CAS No.: 1884220-36-3
Purity: 98.86% Supply Ability: 10g
Release date: 2024/11/13

Product Introduction

Bioactivity

名稱SBI-0206965
描述SBI-0206965 is a potent, selective, and cell-permeable autophagy kinase ULK1 inhibitor with an IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2.
體外活性In HEK293T transfected with WT or KI Myc-tagged ULK1 and WT Vps34, SBI-0206965 inhibits Ser249 phosphorylation of overexpressed Vps34 and Beclin1 Ser15 phosphorylation. SBI-0206965 suppresses autophagy induced by mTOR inhibition in A549 cells, and prevents ULK1-dependent cell survival in WT MEFs. In addition, SBI-0206965 also synergizes with mTOR inhibition to induce cancer cell death. [1]
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 55 mg/mL (112.4 mM)
關(guān)鍵字SBI 0206965 | inhibit | Inhibitor | Unc-51 like kinase | Apoptosis | Autophagy | SBI-0206965 | ULK
相關(guān)產(chǎn)品Stavudine | 5-Fluorouracil | Sodium 4-phenylbutyrate | L-Ascorbic acid | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Tributyrin | Curcumin | Paeonol | Naringin | Gefitinib
相關(guān)庫高選擇性抑制劑庫 | 細(xì)胞凋亡化合物庫 | 表型篩選靶點(diǎn)鑒定庫 | 經(jīng)典已知活性庫 | 激酶抑制劑庫 | 自噬庫 | 抑制劑庫 | NO PAINS 化合物庫 | 抗衰老化合物庫 | 已知活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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$1980.00/50mg
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TargetMol Chemicals Inc.
2024-10-28
$54.00/1mg
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TargetMol Chemicals Inc.
2024-11-13
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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