SB290157 trifluoroacetate NEW
| Price | $43 | $74 | $163 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: SB290157 trifluoroacetate | CAS No.: 1140525-25-2 |
| Purity: 99.89% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | SB290157 trifluoroacetate |
| 描述 | SB290157 trifluoroacetate is a potent and selective antagonist of the C3a receptor, with an IC50 of 200 nM. |
| 體外活性 | SB 290157 is a competitive antagonist of 125I-C3a radioligand binding to rat basophilic leukemia-2H3 cells expressing the human C3aR (RBL-C3aR, IC50 of 200 nM). SB 290157 blocks C3a-induced C3aR internalization in a concentration-dependent manner and C3a-induced Ca2+ mobilization in RBL-C3aR cells and human neutrophils (IC50s of 27.7 and 28 nM, respectively). SB 290157 is selective for the C3aR in that. SB 290157 also inhibits C3a-induced Ca2+ mobilization of RBL-2H3 cells expressing the mouse and guinea pig C3aRs. It potently inhibits C3a-mediated ATP release from guinea pig platelets and inhibits C3a-induced potentiation of the contractile response to field stimulation of perfused rat caudal artery[1]. |
| 體內(nèi)活性 | SB 290157 effectively inhibits neutrophil recruitment in a guinea pig model of LPS-induced airway neutrophilia and reduces paw edema in a rat model of adjuvant-induced arthritis. This antagonist demonstrates a capacity to decrease joint swelling, achieving approximately 50% inhibition at a concentration of 30 mg/kg, but only at the 3-hour mark. Additionally, it significantly lowers C3 levels at 3 hours post-administration, indicating complement consumption compared to naive mice. An increase in C3 activation correlates with the graded concentration of anti-OVA pAb, further showcasing its biological activity (1, 2). |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 125 mg/mL (237.41 mM), Sonication is recommended. |
| 關(guān)鍵字 | SB-290157 trifluoroacetate | SB-290157 Trifluoroacetate | SB290157 trifluoroacetate | SB290157 Trifluoroacetate | SB-290157 | SB290157 | SB 290157 Trifluoroacetate | SB 290157 | Inhibitor | inhibit | Complement System |
| 相關(guān)產(chǎn)品 | EG01377 2HCl | Iptacopan hydrochloride | BCX 1470 hydrochloride | Complement C5-IN-1 | ADH-503 | CP-289 | Dexamethasone | CP-447697 | Complement factor D-IN-2 | Cyclosporin A | 3-Phenoxybenzaldehyde | C3a Receptor Agonist |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 抑制劑庫 | NO PAINS 化合物庫 | 免疫/炎癥分子化合物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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