SB 258719 NEW
Price | $50 | $82 | $166 |
Package | 5mg | 10mg | 25mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-19 |
Product Details
Product Name: SB 258719 | CAS No.: 195199-95-2 |
Purity: 98.59% | Supply Ability: 10g |
Release date: 2024/11/19 |
Product Introduction
Bioactivity
Name | SB 258719 |
Description | SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5. |
In vitro | SB 258719 antagonised surmountably 5-CT-stimulated adenylyl cyclase activity. Schild analysis of the antagonism by SB 258719 gave a pA2 of 7.2±0.2 and slope not significantly different from 1, consistent with competitive antagonism[3]. |
In vivo | SB 258719 (5-20 mg/kg, i.p.) reversed the hypothermic effect of 5-CT in mice[1], attenuated increased Wnt/β-catenin activity in HCC cell lines and patient-derived primary tumor tissues in the presence of 5-HT, and reduced tumor growth in vivo[2]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 250 mg/mL (738.53 mM) |
Keywords | 5-HT Receptor | 5-hydroxytryptamine Receptor | agonism | Inhibitor | inverse | SB258719 | hydrochloride | partial | apparent | selective | inhibit | SB-258719 | SB 258719 | Serotonin Receptor | affinity |
Inhibitors Related | Serotonin hydrochloride | Alverine citrate | Olanzapine | Dapoxetine hydrochloride | CLOZAPINE N-OXIDE | Mirtazapine | Amitriptyline hydrochloride | Cloperastine hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride | Fluoxetine hydrochloride | Cinchonidine |
Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Compound Library | Serotonin Receptor-Targeted Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
Product name | Price | Suppliers | Update time | |
---|---|---|---|---|
$1.00/1KG |
VIP5Y
|
Career Henan Chemica Co
|
2020-10-29 | |
$2500.00/100mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-10-22 | |
$196.00/2mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-10-28 | |
$50.00/5mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-19 |
- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY