SB 202190 hydrochloride NEW
| Price | $42 |
| Package | 2mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-09 |
Product Details
| Product Name: SB 202190 hydrochloride | CAS No.: 350228-36-3 |
| Purity: 99.99% | Supply Ability: 10g |
| Release date: 2025/05/09 |
Product Introduction
Bioactivity
| Name | SB 202190 hydrochloride |
| Description | SB 202190 hydrochloride is the salt form of SB 202190.SB 202190 (FHPI) is a p38 MAPK inhibitor that inhibits p38α and p38β2 with selective, cell-permeable, and antitumor activity, and also induces differentiation of human embryonic stem cells to cardiomyocytes. |
| In vitro | Methods: SB 202190 hydrochloride (0-10 μM, 0-72 hours) was used to treat a subset of colorectal cancer (CRC) cell lines (RKO, CACO2, and SW480), and cell growth was measured. Results: SB 202190 hydrochloride inhibited the growth of a subset of colorectal cancer (CRC) cell lines in a dose- and time-dependent manner. [1] |
| In vivo | Methods: SB 202190 hydrochloride (dissolved in 100% DMSO and then diluted with normal saline (NS) to a final DMSO concentration of 0.1%, injected intracerebroventricularly) was administered to rats, and both the VaD model group and the sham operation group received an equal volume of 0.1% DMSO injected ICV. Eight rats in each group were examined in the Morris water maze to assess spatial learning and memory, six rats were sacrificed and brain sections were prepared for TUNEL staining and Bcl-2/caspase-3 immunohistochemistry, and six rats were sacrificed and tissue homogenates were prepared for Western blot assay of phosphorylated p38 MAPK expression. Results: Compared with the model group, the SB 202190 hydrochloride group showed a significantly shorter escape latency in the Morris water maze hidden platform test; compared with VaD model rats, the SB 202190 hydrochloride group also showed significantly reduced hippocampal neuronal apoptosis (P < 0.01) as well as higher (anti-apoptotic) Bcl-2 expression and lower (pro-apoptotic) caspase-3 expression. [2] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 60 mg/mL (163.13 mM), Sonication and heating are recommended. DMF : 10 mg/mL (27.19 mM), Sonication and heating are recommended. Ethanol:PBS (pH 7.2) (1:10) : < 1 mg/mL, insoluble, Sonication is recommended. Ethanol : 10 mg/mL (27.19 mM), Sonication and heating are recommended. |
| Keywords | SB-202190 Hydrochloride | SB202190 Hydrochloride | SB 202190 hydrochloride |
| Inhibitors Related | Adezmapimod | Exarafenib | Doramapimod | VX-702 | Bakuchiol | p38α inhibitor 3 | SB 202190 | (-)-Bornyl acetate | MW-150 | (E)-Ferulic acid methyl ester | p38-α MAPK-IN-1 | Nisin Z |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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