SantacruzaMate A NEW
| Price | $30 | $45 | $53 |
| Package | 2mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-13 |
Product Details
| Product Name: SantacruzaMate A | CAS No.: 1477949-42-0 |
| Purity: 99.55% | Supply Ability: 10g |
| Release date: 2024/11/13 |
Product Introduction
Bioactivity
| 名稱 | SantacruzaMate A |
| 描述 | SantacruzaMate A (CAY-10683) is a potent and selective HDAC inhibitor. |
| 細(xì)胞實(shí)驗(yàn) | HuT-78 cells incubated in Iscove’s modified Dulbecco’s medium supplemented with 20% FBS, 1% penicillin/streptomycin, and 1% L-glutamine. HCT-116 cells cultivated using McCoy’s 5A medium supplemented with 10% FBS, 1% penicillin/streptomycin, and 1% nonessential amino acids. Cells were seeded in a 96-well plate at 5000cells per well. Before treatment, the plates were incubated at 37°C, 5% CO2 for 24 h. Treatment with inhibitors were incubated in wells for 72 or 96 h using SAHA as a positive control. Antiproliferative activity was determined using a standard MTS-PMS assay. (Only for Reference) |
| 激酶實(shí)驗(yàn) | HDAC Enzyme Assay: The commercially availablae human recombinant enzyme and fluorogenic HDAC assay kits have used to measure percent inhibition and IC50 values of three HDAC isozymes (HDAC2, HDAC4, HDAC6). Briefly, the inhibitor is added sequentially to a black, flat-bottom 96-well microtiter plate, and the reaction mixture is incubated for 30 min at 37°C. The potent HDAC inhibitor trichostatin A (included in the assay kit) is added to the bifunctional HDAC assay developer at a final reaction concentration of 1 μM to stop deacetylation and initiate the release of the fluorophore. The reaction mixture is further incubated at room temperature for 15 min. Fluorescence is measured on a Spectra Max Gemini XPS using an excitation wavelength of 360 nm and a detection wavelength of 460 nm. |
| 體內(nèi)活性 | Santacruzamate A inhibits the growth of HCT116 colon cancer cells and HuT-78 cutaneous T-cell lymphoma cells, with GI50 values of 29.4 μM and 1.4 μM, respectively. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 51 mg/mL (183.2 mM) Ethanol : 51 mg/mL (183.2 mM) |
| 關(guān)鍵字 | Inhibitor | SantacruzaMate A | inhibit | Histone deacetylases | CAY10683 | HDAC | CAY 10683 |
| 相關(guān)產(chǎn)品 | Exifone | Valproic acid sodium salt | Panobinostat | Theophylline monohydrate | Sodium 4-phenylbutyrate | Vorinostat | HDAC8-IN-1 | RGFP966 | Parthenolide | Ricolinostat | 4-Phenylbutyric acid | Methyl L-histidinate dihydrochloride |
| 相關(guān)庫(kù) | 高選擇性抑制劑庫(kù) | 抗癌天然產(chǎn)物庫(kù) | DNA 損傷和修復(fù)分子庫(kù) | 經(jīng)典已知活性庫(kù) | 天然產(chǎn)物庫(kù) | 微生物天然產(chǎn)物庫(kù) | 抑制劑庫(kù) | 高通量篩選天然產(chǎn)物庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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