Salinomycin NEW
| Price | $32 | $45 | $74 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Salinomycin | CAS No.: 53003-10-4 |
| Purity: 98.00% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Salinomycin |
| Description | Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, specifically inhibits the growth of gram-positive bacteria, acts as a potent inhibitor of Wnt/β-catenin signaling by blocking Wnt-induced LRP6 phosphorylation, and demonstrates selective activity against human cancer stem cells. |
| In vitro | Salinomycin, a potent Wnt signaling cascade inhibitor and antibiotic potassium ionophore, demonstrates significant anticancer properties. It induces apoptosis in malignant lymphocytes within 48 hours, showing a mean IC50 value of 230 nM. Notably, Salinomycin has been identified as a selective inhibitor of breast cancer stem cells (CSCs)[1], effectively inhibiting both normal and Cisp-resistant SW620 cancer cells with IC50 values of 1.54±0.23 μM and 0.32±0.05 μM, respectively. It uniquely targets and kills CSCs and therapy-resistant cancer cells. Continuous treatment with Salinomycin over 48 hours increases the apoptotic cell count significantly in Cisp-resistant SW620 cells compared to non-resistant SW620 cells, as observed under a microscope and confirmed through flow cytometric analysis of cell apoptosis. The apoptotic rate is markedly higher in Cisp-resistant SW620 cells (37.82±3.63%) than in standard SW620 cells (16.78±2.56%) (p<0.05)[2]. |
| In vivo | Upon administering doses of 4 mg/kg and 8 mg/kg Salinomycin (Sal), alongside 10 uL/g saline water to mice for a duration of 6 weeks, followed by their sacrifice, a significant reduction in liver tumor size is observed in the Sal-treated groups compared to the controls. Tumor diameters decrease notably from 12.17 mm to 3.67 mm (p<0.05), and volumes, calculated as V=length×width^2×0.5, diminish from 819 mm^3 to 25.25 mm^3 (p<0.05). Subsequent analyses, involving HE staining, immunohistochemistry, and TUNEL assays, are conducted to evaluate Salinomycin's anti-tumor efficacy. Results show altered liver cancer tissue structure, reduced PCNA expression, and higher apoptosis rates in Sal-treated mice, indicating significant anti-tumor activity. Furthermore, an increase in the Bax/Bcl-2 ratio and a decrease in β-catenin protein expression corroborate Salinomycin's effectiveness. Salinomycin, a monocarboxylic acid polyether antibiotic derived from Streptomyces albus fermentation, exhibits a unique cyclic structure enabling it to bind with pathogenic microorganisms and extracellular cations of coccidia, particularly K+, Na+, Rb+, effectively altering intra- and extracellular ion concentrations[4][5]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 35 mg/mL (46.6 mM), Sonication is recommended. |
| Keywords | Salinomycin |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | Natural Product Library | Neuroprotective Compound Library | Microbial Natural Product Library | Inhibitor Library | Natural Product Library for HTS | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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