(S)-(-)-Levamisole
| Price | $10 |
| Package | 1kg |
| Min. Order: | 1kg |
| Supply Ability: | Ex 20 tons |
| Update Time: | 2022-10-22 |
Product Details
| Product Name: (S)-(-)-Levamisole | CAS No.: 14769-73-4 |
| EC-No.: 238-836-5 | Min. Order: 1kg |
| Purity: 99% | Supply Ability: Ex 20 tons |
| Release date: 2022/10/22 |
Use of (S)-(-)-Levamisole
(S)-(-)-Levamisole (Levamisole), an anthelmintic agent with immunomodulatory properties. (S)-(-)-Levamisole acts as a positive allosteric modulator (PAM) for the α3β2 (EC50=300 μM) and α3β4 (EC50=100 μM) subtype of nAChRs. Orally active[1][2].
| Name | levamisole |
|---|---|
| Synonym | More Synonyms |
| Description | (S)-(-)-Levamisole (Levamisole), an anthelmintic agent with immunomodulatory properties. (S)-(-)-Levamisole acts as a positive allosteric modulator (PAM) for the α3β2 (EC50=300 μM) and α3β4 (EC50=100 μM) subtype of nAChRs. Orally active[1][2]. |
|---|---|
| Related Catalog | Research Areas >> Infection Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Inflammation/Immunology |
| In Vivo | (S)-(-)-Levamisole (Levamisole) (50 μg/ml and 200 μg/ml; p.o.; 30 days) prevents weight gain in mice that were fed a high fat diet[2]. |
| Storage | Powder-20°C3 years4°C2 yearsIn solvent-80°C6 months-20°C1 month |
| Shipping | Room temperature |
| References | [1]. Lewis JA, et al. Levamisole: A Positive Allosteric Modulator for the α3β4 Nicotinic Acetylcholine Receptors Prevents Weight Gain in the CD-1 Mice on a High Fat Diet. Curr Pharm Des. 2017;23(12):1869-1872. [2]. Mehta KP, et al. Immunoregulatory treatment for minimal change nephrotic syndrome. Arch Dis Child. 1986;61(2):153-158. |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 344.4±45.0 °C at 760 mmHg |
| Melting Point | 230 - 233oC |
| Molecular Formula | C11H12N2S |
| Molecular Weight | 204.291 |
| Flash Point | 162.1±28.7 °C |
| Exact Mass | 204.072113 |
| PSA | 40.90000 |
| LogP | 1.85 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.713 |
| Storage condition | 0-6°C |
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