Product Details
| Product Name:
Roxindole |
CAS No.:
112192-04-8 |
| Purity:
99.18% |
Supply Ability:
10g |
| Release date:
2024/11/17 |
Product Introduction
Bioactivity
| 名稱 | Roxindole |
| 描述 | Roxindole (EMD 49980) is a selective dopamine autoreceptor and 5-HT1A dual agonist and inhibitor of 5-hydroxytryptamine (5-HT) uptake with antipsychotic and antidepressant activity.Roxindole can be used to study Parkinson's and neurodivergence. |
| 體外活性 | Roxindole has high affinity for hD3 as well as hD2 (short isomer) and hD4 (4-repeat isomer) receptors (pKi values of 8.93, 8.55 and 8.23, respectively). In addition, it had a high affinity for the hS-HT1A receptor (pKi = 9.42), but a low affinity for the 5-HT1B and 5-HT1D receptors (pKi values of 6.00 and 7.05, respectively). [1] |
| 體內活性 | Roxindole（EMD 49980） inhibited apomorphine-induced climbing behavior in mice and stereotyped behavior in rats with ED50 of 1.4 mg/kg s.c. and 0.65 mg/kg s.c., respectively, and also inhibited conditioned avoidance responses in rats (ED50 = 1. 5 mg/kg s.c) [2];In the paradigm of co-treatment with haloperidol (1 mg/kg per day, orally), Roxindole（EMD 49980） (10 mg/kg per day, orally) did not alter the behavioral hypersensitivity measured after the drug washout phase as compared with the effect of haloperidol alone; if administration of Roxindole（EMD 49980） (10 mg/kg, i.v.) after the drug washout phase induced only weak stereotyped behaviors in haloperidol-hypersensitized rats, Roxindole（EMD 49980） did not induce either desensitization of the presynaptic or supersensitivity of the postsynaptic dopamine D2 receptor[3]; Roxindole (EMD 49980) (1, 3, 10 mg/kg; s.c) inhibits both effects of 8-OH-DPAT (flattened body and forepaw stamping) in normal rats (male Wistar 200-350g) [5]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 關鍵字 | Roxindole |
| 相關產(chǎn)品 | Alverine citrate | Dapoxetine hydrochloride | CLOZAPINE N-OXIDE | Octopamine hydrochloride | Citicoline | Oxolinic acid | Trazodone hydrochloride | Mianserin hydrochloride |
| 相關庫 | 經(jīng)典已知活性庫 | 疼痛相關化合物庫 | 已知活性化合物庫 | GPCR靶點分子庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$1530.00/100mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-10-23 |
United States