Ro 10-5824 dihydrochloride NEW
| Price | $29 | $46 | $78 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Ro 10-5824 dihydrochloride | CAS No.: 189744-94-3 |
| Purity: 99.95% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Ro 10-5824 dihydrochloride |
| Description | Ro 10-5824 dihydrochloride is a selective partial agonist of the dopamine D4 receptor, with a Ki of 5.2 nM. |
| In vitro | RO-10-5824 exhibits high affinity binding (Ki=5.2±0.9 nM (n=3)), 250-fold selectivity over human D3R, and >1000-fold selectivity for D4 versus human D2, D1, and D5 receptors. It stimulates 35S-GTPγS binding (EC50: 205±67 nM) (n=7) with a maximal induction of 36±4% above basal level [2]. |
| In vivo | The success rate in the ORD task increased by Ro 10-5824 (3 mg/kg). At doses of 1 and 3 mg/kg, in the frontal cortex, Ro 10-5824 increases baseline gamma band activity. RO-10-5824 (10.0 mg/kg) does not increase center entries in the open field in a single 60-min session without the novel object present, nor does it increase overall transitions in the initial experiment with C57 mice[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 60 mg/mL (169.83 mM) DMSO : 8.33 mg/mL (23.58 mM), Sonication is recommended. |
| Keywords | Inhibitor | inhibit | Ro 105824 dihydrochloride | Ro 10-5824 Dihydrochloride | Dopamine Receptor | Ro 10-5824 | Ro 10 5824 dihydrochloride |
| Inhibitors Related | Olanzapine | CLOZAPINE N-OXIDE | Mirtazapine | Promazine hydrochloride | Octopamine hydrochloride | Octodrine | Citicoline | Phenothiazine | Oxolinic acid | Mianserin hydrochloride | Doxepin hydrochloride | Fluphenazine dihydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Neuronal Signaling Compound Library | Antidepressant Compound Library | Membrane Protein-targeted Compound Library | Anti-Parkinson's Disease Compound Library | Neurotransmitter Receptor Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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