Product Details
| Product Name:
Resistomycin |
CAS No.:
20004-62-0 |
| Purity:
99.02% |
Supply Ability:
10g |
| Release date:
2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | Resistomycin |
| 描述 | Resistomycin (Geliomycin), a pentacyclic polyketide antibiotic, exhibits potent anticancer properties by triggering apoptosis. |
| 體外活性 | Resistomycin effectively impedes the advancement of triple-negative breast cancer (TNBC) by targeting and inhibiting E3 ligase Pellino-1, which leads to the degradation of SNAIL/SLUG proteins. It binds strongly to GST-Pellino-1, with a dissociation constant (KD) of 2.58 μM, as demonstrated through surface plasmon resonance [1]. Additionally, Resistomycin administration has been shown to decrease SNAIL and SLUG protein levels in TNBC cells [1]. Furthermore, it has been found to provoke apoptosis and cell cycle arrest in human hepatocellular carcinoma cells by activating the p38 MAPK pathway, both in laboratory settings and in animal models [2]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 3.33 mg/mL (8.86 mM), Sonication is recommended.
|
| 關(guān)鍵字 | Resistomycin |
| 相關(guān)產(chǎn)品 | Neomycin sulfate | Rifampicin | Ampicillin sodium | Doxycycline (hyclate) | Kanamycin sulfate | G-418 disulfate | Sulfamethoxazole sodium | Metronidazole | Doxycycline | EDTA copper(II) disodium salt |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 微生物天然產(chǎn)物庫(kù) | 已知活性化合物庫(kù) | 抗癌化合物庫(kù) | 抗癌活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States