- (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid 
- (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid is a white to off-white solid with a molecular weight of 409.52 g/mol and a molecular formula of C25H31NO4.
- It has a boiling point of 562.7±50.0 °C and a density of 1.081±0.06 g/cm3.
- It has a pKa of 11.14±0.46  and is soluble in tetrahydrofuran.
- It is also known as (R)-Ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoate.
- Its use is as an intermediate for sacubitril valsartan sodium, and introduce the use of sacubitril valsartan sodium.
- Sacubitril valsartan sodium is a combination drug that contains sacubitril, a neprilysin inhibitor, and valsartan, an angiotensin II receptor blocker.
- It is used to treat heart failure with reduced ejection fraction.
- It works by enhancing the protective neurohormonal systems of the heart and inhibiting the harmful ones.

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