Product Details
| Product Name:
RCGD423 |
CAS No.:
108237-91-8 |
| Purity:
99.14% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | RCGD423 |
| Description | RCGD423, a small molecule gp130 modulator, prevents articular cartilage degeneration and promotes repair. |
| In vitro | The ability of RCGD 423 to inhibit hypertrophy in human cells was confirmed by assessing RUNX2 and COL 10 levels in healthy and osteoarthritic articular chondrocytes following incubation with the compound. RCGD 423 elicited a unique signaling profile, driving strong increases in pSTAT3 and MYC levels without activating AKT or NF-κB, resulting in a signaling milieu downstream of gp130 similar to actively proliferating and anabolic fetal chondrocytes. |
| In vivo | Operated animals would receive an intra-articular injection of 4 μg RCGD 423 loaded onto microspheres at the time of surgery and another 3weeks later. In RCGD 423-treated animals, there was little to no cartilage degradation, structural damage or generation of osteophytes. Control animals showed increased levels of cartilage-degrading proteins and markers of hypertrophy, while these were mostly absent in RCGD 423-treated rats. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : Insoluble
DMSO : 150 mg/mL (452.86 mM)
|
| Keywords | RCGD-423 | RCGD423 | inhibit | Inhibitor | Interleukin Related | RCGD 423 |
| Inhibitors Related | Sodium Thiocyanate | Disulfiram | Deucravacitinib | Apilimod mesylate | Hydrocortisone hemisuccinate | JAK2/STAT3-IN-1 | Y-320 | Balsalazide sodium hydrate | Vidofludimus | Muscone | Apilimod | SC144 |
| Related Compound Libraries | Nonsteroidal Anti-Inflammatory Compound Library | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States