Product Details
| Product Name:
Raxofelast |
CAS No.:
128232-14-4 |
| Purity:
99.89% |
Supply Ability:
10g |
| Release date:
2024/11/13 |
Product Introduction
Bioactivity
| 名稱 | Raxofelast |
| 描述 | Raxofelast (IRFI-016) is a hydrophilic, non-systemic, vitamin-like antioxidant that reduces ischemia-reperfusion injury in testis. Raxofelast is a good candidate compound for stopping oxidative stress after acute testicular torsion. Raxofelast has the potential to treat diabetic complications and atherosclerosis. |
| 體外活性 | In glial cells, We evaluated the power of the antioxidants genistein and Raxofelast (20-80 microM), compared with glutathione ethyl ester and cysteamine-HCl, to antagonize the effects elicited by glutamate. Alterations of cell redox status were reduced, in a dose-dependent way, by antioxidants; Raxofelast (80 microM) and genistein (10 microM) almost completely restored glutathione basal levels and significantly diminished ROS production, as well as 100 microM glutathione ethyl ester. These antioxidant effects were stronger than those caused by 500 microM cysteamine-HCl. The activation of p50 and p65 NF-kappaB subunits induced by glutamate exposure was significantly reduced by Raxofelast, acting in a dose-dependent manner. [1] |
| 體內(nèi)活性 | The effects of IRFI-016 [2(2,3 Dihydro-5-Acetoxy 4,6,7-Trimethyl-Benzofuranyl) acetic acid] a new radical scavenger were studied following six hours of myocardial ischemia, induced by left coronary artery occlusion in male rats. Occlusion of the coronary artery, furthermore, was associated with an immediate rise in the ST segment of the ECG, which was significantly attenuated by IRFI-016. These findings further suggest that IRFI-016 may be a useful agent in the treatment of myocardial occlusion injury.[2] We have investigated the therapeutic efficacy of raxofelast in rats subjected to carrageenan-induced pleurisy. In vivo, treatment with raxofelast (5, 10, 20 mg kg(-1) intraperitoneally 5 min before carrageenan) prevented in a dose-dependent manner carrageenan-induced pleural exudation and polymorphonuclear migration in rats subjected to carrageenan-induced pleurisy. Lung myeloperoxidase (MPO) activity and malondialdehyde (MDA) levels, as well as histological organ injury, were significantly reduced by raxofelast. Raxofelast (5, 10, 20 mg kg(-1)) treatment significantly reduced peroxynitrite formation as measured prevented the appearance of DNA damage, the decrease in mitochondrial respiration and partially restored the cellular level of NAD+ in ex vivo macrophages harvested from the pleural cavity of rats subjected to carrageenan-induced pleurisy. In conclusion, Study demonstrates that raxofelast, a new hydrophilic vitamin E-like antioxidant agent, exerts multiple protective effects in carrageenan-induced acute inflammation.[3] |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (179.66 mM)
|
| 關(guān)鍵字 | Raxofelast |
| 相關(guān)產(chǎn)品 | Thiamine monochloride | 2-Heptanol | Butylated hydroxytoluene | Hydroquinone diacetate | Methyl 3,4-dihydroxybenzoate | Propyl gallate | L-Tartaric acid | Neohesperidin | Sulbutiamine | m-Coumaric acid | L-Cystine | Trolox |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 抗氧化化合物庫 | 抗衰老化合物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States