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Postion:Product Catalog >API>Antiparasitic drugs>Anthelmintics>Pyrvinium pamoate
Pyrvinium pamoate
  • Pyrvinium pamoate

Pyrvinium pamoate NEW

Price $31 $48 $81
Package 5mg 10mg 50mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-15

Product Details

Product Name: Pyrvinium pamoate CAS No.: 3546-41-6
Purity: 98.43% Supply Ability: 10g
Release date: 2024/11/15

Product Introduction

Bioactivity

名稱Pyrvinium pamoate
描述Pyrvinium pamoate (Pyrvinium embonate) is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug due to its inhibition of Wnt/β-catenin pathway in some types of cancer.
體外活性Pyrvinium pamoate treatment repressed the phosphorylation of GSK3β at S9 which might be mediated by AKT, and decreased the protein levels of β-catenin and its downstream targets (c-Myc, cyclin D1). Pyrvinium pamoate remarkably inhibited cell viability and colony formation ability. Treatment with pyrvinium pamoate induced intrinsic pathway-dependent apoptosis accompanied with a decline of anti-apoptotic XIAP and Survivin, and an overt increase of pro-apoptotic Bax. In addition, pyrvinium pamoate significantly inhibited the migration and invasion in vitro[1].
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 12 mg/mL (20.84 mM)
關(guān)鍵字inhibit | Pyrvinium | Inhibitor | Pyrvinium pamoate | Wnt
相關(guān)產(chǎn)品Urea | PRI-724 | Wnt pathway activator 1 | L-quebrachitol | MSAB | EMT inhibitor-1 | XAV-939 | Nefopam hydrochloride | KY-05009 | Bisdemethoxycurcumin

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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